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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structure, Activity Regulation, and Role of the Mitochondrial Calcium Uniporter in Health and Disease
|
|---|---|
| Published in |
Frontiers in oncology, July 2017
|
| DOI | 10.3389/fonc.2017.00139 |
| Pubmed ID | |
| Authors |
Cristina Mammucari, Gaia Gherardi, Rosario Rizzuto |
| Abstract |
Mitochondrial Ca(2+) uptake plays a pivotal role both in cell energy balance and in cell fate determination. Studies on the role of mitochondrial Ca(2+) signaling in pathophysiology have been favored by the identification of the genes encoding the mitochondrial calcium uniporter (MCU) and its regulatory subunits. Thus, research carried on in the last years on one hand has determined the structure of the MCU complex and its regulation, on the other has uncovered the consequences of dysregulated mitochondrial Ca(2+) signaling in cell and tissue homeostasis. Whether mitochondrial Ca(2+) uptake can be exploited as a weapon to counteract cancer progression is debated. In this review, we summarize recent research on the molecular structure of the MCU, the regulatory mechanisms that control its activity and its relevance in pathophysiology, focusing in particular on its role in cancer progression. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 122 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 22% |
| Student > Master | 16 | 13% |
| Researcher | 14 | 11% |
| Student > Bachelor | 10 | 8% |
| Professor | 5 | 4% |
| Other | 14 | 11% |
| Unknown | 36 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 43 | 35% |
| Agricultural and Biological Sciences | 13 | 11% |
| Engineering | 6 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Medicine and Dentistry | 5 | 4% |
| Other | 15 | 12% |
| Unknown | 35 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2017.
All research outputs
#15,745,807
of 25,382,440 outputs
Outputs from Frontiers in oncology
#4,970
of 22,428 outputs
Outputs of similar age
#178,915
of 325,228 outputs
Outputs of similar age from Frontiers in oncology
#36
of 77 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,428 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,228 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.