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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis
|
|---|---|
| Published in |
Frontiers in oncology, March 2018
|
| DOI | 10.3389/fonc.2018.00055 |
| Pubmed ID | |
| Authors |
Maria Kalli, Triantafyllos Stylianopoulos |
| Abstract |
Solid tumors are characterized by an abnormal stroma that contributes to the development of biomechanical abnormalities in the tumor microenvironment. In particular, these abnormalities include an increase in matrix stiffness and an accumulation of solid stress in the tumor interior. So far, it is not clearly defined whether matrix stiffness and solid stress are strongly related to each other or they have distinct roles in tumor progression. Moreover, while the effects of stiffness on tumor progression are extensively studied compared to the contribution of solid stress, it is important to ascertain the biological outcomes of both abnormalities in tumorigenesis and metastasis. In this review, we discuss how each of these parameters is evolved during tumor growth and how these parameters are influenced by each other. We further review the effects of matrix stiffness and solid stress on the proliferative and metastatic potential of cancer and stromal cells and summarize the in vitro experimental setups that have been designed to study the individual contribution of these parameters. |
X Demographics
The data shown below were collected from the profiles of 54 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Cyprus | 2 | 4% |
| Serbia | 2 | 4% |
| Philippines | 2 | 4% |
| Switzerland | 2 | 4% |
| United States | 2 | 4% |
| Tanzania, United Republic of | 2 | 4% |
| Venezuela, Bolivarian Republic of | 2 | 4% |
| Spain | 1 | 2% |
| Ethiopia | 1 | 2% |
| Other | 9 | 17% |
| Unknown | 29 | 54% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 40 | 74% |
| Scientists | 10 | 19% |
| Practitioners (doctors, other healthcare professionals) | 4 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 304 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 304 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 72 | 24% |
| Student > Master | 38 | 13% |
| Researcher | 29 | 10% |
| Student > Bachelor | 24 | 8% |
| Student > Doctoral Student | 22 | 7% |
| Other | 33 | 11% |
| Unknown | 86 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 70 | 23% |
| Engineering | 52 | 17% |
| Agricultural and Biological Sciences | 23 | 8% |
| Chemical Engineering | 12 | 4% |
| Materials Science | 8 | 3% |
| Other | 39 | 13% |
| Unknown | 100 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2021.
All research outputs
#1,116,485
of 25,382,440 outputs
Outputs from Frontiers in oncology
#186
of 22,428 outputs
Outputs of similar age
#25,120
of 350,479 outputs
Outputs of similar age from Frontiers in oncology
#7
of 118 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,428 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 350,479 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 118 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.