Title |
Metabolic Reprogramming in Thyroid Carcinoma
|
---|---|
Published in |
Frontiers in oncology, March 2018
|
DOI | 10.3389/fonc.2018.00082 |
Pubmed ID | |
Authors |
Raquel Guimaraes Coelho, Rodrigo S. Fortunato, Denise P. Carvalho |
Abstract |
Among all the adaptations of cancer cells, their ability to change metabolism from the oxidative to the glycolytic phenotype is a hallmark called the Warburg effect. Studies on tumor metabolism show that improved glycolysis and glutaminolysis are necessary to maintain rapid cell proliferation, tumor progression, and resistance to cell death. Thyroid neoplasms are common endocrine tumors that are more prevalent in women and elderly individuals. The incidence of thyroid cancer has increased in the Past decades, and recent findings describing the metabolic profiles of thyroid tumors have emerged. Currently, several drugs are in development or clinical trials that target the altered metabolic pathways of tumors are undergoing. We present a review of the metabolic reprogramming in cancerous thyroid tissues with a focus on the factors that promote enhanced glycolysis and the possible identification of promising metabolic targets in thyroid cancer. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 70 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 16% |
Researcher | 8 | 11% |
Student > Bachelor | 7 | 10% |
Student > Master | 6 | 9% |
Student > Doctoral Student | 4 | 6% |
Other | 7 | 10% |
Unknown | 27 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 20% |
Medicine and Dentistry | 9 | 13% |
Agricultural and Biological Sciences | 7 | 10% |
Veterinary Science and Veterinary Medicine | 2 | 3% |
Immunology and Microbiology | 2 | 3% |
Other | 8 | 11% |
Unknown | 28 | 40% |