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X Demographics
Mendeley readers
Attention Score in Context
| Title |
“Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway
|
|---|---|
| Published in |
Frontiers in oncology, July 2018
|
| DOI | 10.3389/fonc.2018.00287 |
| Pubmed ID | |
| Authors |
Emira Bousoik, Hamidreza Montazeri Aliabadi |
| Abstract |
Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in signal transduction initiated by a wide range of membrane receptors. Among the proteins in this family JAK2 has been associated with important downstream proteins, including signal transducers and activators of transcription (STATs), which in turn regulate the expression of a variety of proteins involved in induction or prevention of apoptosis. Therefore, the JAK/STAT signaling axis plays a major role in the proliferation and survival of different cancer cells, and may even be involved in resistance mechanisms against molecularly targeted drugs. Despite extensive research focused on the protein structure and mechanisms of activation of JAKs, and signal transduction through these proteins, their importance in cancer initiation and progression seem to be underestimated. This manuscript is an attempt to highlight the role of JAK proteins in cancer biology, the most recent developments in targeting JAKs, and the central role they play in intracellular cross-talks with other signaling cascades. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 2 | 22% |
| United States | 1 | 11% |
| Switzerland | 1 | 11% |
| Unknown | 5 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 89% |
| Scientists | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 476 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 476 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 71 | 15% |
| Student > Ph. D. Student | 68 | 14% |
| Student > Master | 59 | 12% |
| Researcher | 47 | 10% |
| Student > Doctoral Student | 17 | 4% |
| Other | 43 | 9% |
| Unknown | 171 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 113 | 24% |
| Medicine and Dentistry | 47 | 10% |
| Agricultural and Biological Sciences | 41 | 9% |
| Immunology and Microbiology | 24 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 23 | 5% |
| Other | 39 | 8% |
| Unknown | 189 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2023.
All research outputs
#1,336,842
of 25,820,938 outputs
Outputs from Frontiers in oncology
#226
of 22,806 outputs
Outputs of similar age
#27,322
of 341,893 outputs
Outputs of similar age from Frontiers in oncology
#3
of 151 outputs
Altmetric has tracked 25,820,938 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,806 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,893 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 151 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.