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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Involvement of Synaptic Genes in the Pathogenesis of Autism Spectrum Disorders: The Case of Synapsins
|
|---|---|
| Published in |
Frontiers in Pediatrics, September 2014
|
| DOI | 10.3389/fped.2014.00094 |
| Pubmed ID | |
| Authors |
Silvia Giovedí, Anna Corradi, Anna Fassio, Fabio Benfenati |
| Abstract |
Autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders characterized by deficits in social interaction and social communication, restricted interests, and repetitive behaviors. Many synaptic protein genes are linked to the pathogenesis of ASDs, making them prototypical synaptopathies. An array of mutations in the synapsin (Syn) genes in humans has been recently associated with ASD and epilepsy, diseases that display a frequent comorbidity. Syns are pre-synaptic proteins regulating synaptic vesicle traffic, neurotransmitter release, and short-term synaptic plasticity. In doing so, Syn isoforms control the tone of activity of neural circuits and the balance between excitation and inhibition. As ASD pathogenesis is believed to result from dysfunctions in the balance between excitatory and inhibitory transmissions in neocortical areas, Syns are novel ASD candidate genes. Accordingly, deletion of single Syn genes in mice, in addition to epilepsy, causes core symptoms of ASD by affecting social behavior, social communication, and repetitive behaviors. Thus, Syn knockout mice represent a good experimental model to define synaptic alterations involved in the pathogenesis of ASD and epilepsy. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | <1% |
| Israel | 1 | <1% |
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 131 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 24% |
| Researcher | 18 | 13% |
| Student > Bachelor | 17 | 13% |
| Student > Master | 11 | 8% |
| Student > Doctoral Student | 8 | 6% |
| Other | 18 | 13% |
| Unknown | 31 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 32 | 24% |
| Agricultural and Biological Sciences | 26 | 19% |
| Medicine and Dentistry | 17 | 13% |
| Biochemistry, Genetics and Molecular Biology | 10 | 7% |
| Psychology | 8 | 6% |
| Other | 7 | 5% |
| Unknown | 36 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2014.
All research outputs
#21,506,435
of 26,399,279 outputs
Outputs from Frontiers in Pediatrics
#4,384
of 8,084 outputs
Outputs of similar age
#184,420
of 249,928 outputs
Outputs of similar age from Frontiers in Pediatrics
#22
of 38 outputs
Altmetric has tracked 26,399,279 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,084 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,928 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.