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Inherited Thrombophilia in Pediatric Venous Thromboembolic Disease: Why and Who to Test

Overview of attention for article published in Frontiers in Pediatrics, March 2017
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Title
Inherited Thrombophilia in Pediatric Venous Thromboembolic Disease: Why and Who to Test
Published in
Frontiers in Pediatrics, March 2017
DOI 10.3389/fped.2017.00050
Pubmed ID
Authors

C. Heleen van Ommen, Ulrike Nowak-Göttl

Abstract

Venous thromboembolic disease in childhood is a multifactorial disease. Risk factors include acquired clinical risk factors such as a central venous catheter and underlying disease and inherited thrombophilia. Inherited thrombophilia is defined as a genetically determined tendency to develop venous thromboembolism. In contrast to adults, acquired clinical risk factors play a larger role than inherited thrombophilia in the development of thrombotic disease in children. The contributing role of inherited thrombophilia is not clear in many pediatric thrombotic events, especially catheter-related thrombosis. Furthermore, identification of inherited thrombophilia will not often influence acute management of the thrombotic event as well as the duration of anticoagulation. In some patients, however, detection of inherited thrombophilia may lead to identification of other family members who can be counseled for their thrombotic risk. This article discusses the potential arguments for testing of inherited thrombophilia, including factor V Leiden mutation, prothrombin mutation, and deficiencies of antithrombin, protein C, or protein S and suggests some patient groups in childhood, which may be tested.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 61 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 7 11%
Other 6 10%
Researcher 6 10%
Student > Master 6 10%
Student > Doctoral Student 4 7%
Other 12 20%
Unknown 20 33%
Readers by discipline Count As %
Medicine and Dentistry 27 44%
Unspecified 3 5%
Agricultural and Biological Sciences 3 5%
Biochemistry, Genetics and Molecular Biology 2 3%
Nursing and Health Professions 2 3%
Other 2 3%
Unknown 22 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2017.
All research outputs
#18,538,272
of 22,959,818 outputs
Outputs from Frontiers in Pediatrics
#3,379
of 6,021 outputs
Outputs of similar age
#235,064
of 307,966 outputs
Outputs of similar age from Frontiers in Pediatrics
#60
of 81 outputs
Altmetric has tracked 22,959,818 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,021 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,966 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.