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Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure–Activity Relationships, and Molecular Mechanisms of Action

Overview of attention for article published in Frontiers in Pharmacology, January 2012
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  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

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3 X users
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1 Facebook page

Citations

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285 Dimensions

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148 Mendeley
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Title
Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure–Activity Relationships, and Molecular Mechanisms of Action
Published in
Frontiers in Pharmacology, January 2012
DOI 10.3389/fphar.2012.00025
Pubmed ID
Authors

Subhasree Ashok Nag, Jiang-Jiang Qin, Wei Wang, Ming-Hai Wang, Hui Wang, Ruiwen Zhang

Abstract

Conventional chemotherapeutic agents are often toxic not only to tumor cells but also to normal cells, limiting their therapeutic use in the clinic. Novel natural product anticancer compounds present an attractive alternative to synthetic compounds, based on their favorable safety and efficacy profiles. Several pre-clinical and clinical studies have demonstrated the anticancer potential of Panax ginseng, a widely used traditional Chinese medicine. The anti-tumor efficacy of ginseng is attributed mainly to the presence of saponins, known as ginsenosides. In this review, we focus on how ginsenosides exert their anticancer effects by modulation of diverse signaling pathways, including regulation of cell proliferation mediators (CDKs and cyclins), growth factors (c-myc, EGFR, and vascular endothelial growth factor), tumor suppressors (p53 and p21), oncogenes (MDM2), cell death mediators (Bcl-2, Bcl-xL, XIAP, caspases, and death receptors), inflammatory response molecules (NF-κB and COX-2), and protein kinases (JNK, Akt, and AMP-activated protein kinase). We also discuss the structure-activity relationship of various ginsenosides and their potentials in the treatment of various human cancers. In summary, recent advances in the discovery and evaluation of ginsenosides as cancer therapeutic agents support further pre-clinical and clinical development of these agents for the treatment of primary and metastatic tumors.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 <1%
Austria 1 <1%
Unknown 146 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 26 18%
Student > Bachelor 20 14%
Student > Ph. D. Student 18 12%
Researcher 13 9%
Student > Doctoral Student 12 8%
Other 25 17%
Unknown 34 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 23%
Biochemistry, Genetics and Molecular Biology 21 14%
Medicine and Dentistry 16 11%
Pharmacology, Toxicology and Pharmaceutical Science 13 9%
Engineering 5 3%
Other 18 12%
Unknown 41 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2021.
All research outputs
#13,864,373
of 23,493,900 outputs
Outputs from Frontiers in Pharmacology
#4,313
of 17,051 outputs
Outputs of similar age
#150,250
of 247,547 outputs
Outputs of similar age from Frontiers in Pharmacology
#58
of 138 outputs
Altmetric has tracked 23,493,900 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 17,051 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,547 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 138 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.