Title |
The KCNE Tango – How KCNE1 Interacts with Kv7.1
|
---|---|
Published in |
Frontiers in Pharmacology, January 2012
|
DOI | 10.3389/fphar.2012.00142 |
Pubmed ID | |
Authors |
Eva Wrobel, Daniel Tapken, Guiscard Seebohm |
Abstract |
The classical tango is a dance characterized by a 2/4 or 4/4 rhythm in which the partners dance in a coordinated way, allowing dynamic contact. There is a surprising similarity between the tango and how KCNE β-subunits "dance" to the fast rhythm of the cell with their partners from the Kv channel family. The five KCNE β-subunits interact with several members of the Kv channels, thereby modifying channel gating via the interaction of their single transmembrane-spanning segment, the extracellular amino terminus, and/or the intracellular carboxy terminus with the Kv α-subunit. Best studied is the molecular basis of interactions between KCNE1 and Kv7.1, which, together, supposedly form the native cardiac I(Ks) channel. Here we review the current knowledge about functional and molecular interactions of KCNE1 with Kv7.1 and try to summarize and interpret the tango of the KCNEs. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Poland | 1 | 2% |
Canada | 1 | 2% |
Unknown | 46 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 21% |
Student > Bachelor | 9 | 19% |
Researcher | 8 | 17% |
Student > Doctoral Student | 6 | 13% |
Student > Postgraduate | 3 | 6% |
Other | 9 | 19% |
Unknown | 3 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 27% |
Medicine and Dentistry | 13 | 27% |
Biochemistry, Genetics and Molecular Biology | 7 | 15% |
Neuroscience | 4 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Other | 4 | 8% |
Unknown | 4 | 8% |