Title |
In utero hematopoietic cell transplantation for hemoglobinopathies
|
---|---|
Published in |
Frontiers in Pharmacology, January 2015
|
DOI | 10.3389/fphar.2014.00278 |
Pubmed ID | |
Authors |
S. Christopher Derderian, Cerine Jeanty, Mark C. Walters, Elliott Vichinsky, Tippi C. MacKenzie |
Abstract |
In utero hematopoietic cell transplantation (IUHCTx) is a promising strategy to circumvent the challenges of postnatal hematopoietic stem cell (HSC) transplantation. The goal of IUHCTx is to introduce donor cells into a naïve host prior to immune maturation, thereby inducing donor-specific tolerance. Thus, this technique has the potential of avoiding host myeloablative conditioning with cytotoxic agents. Over the past two decades, several attempts at IUHCTx have been made to cure numerous underlying congenital anomalies with limited success. In this review, we will briefly review the history of IUHCTx and give a perspective on alpha thalassemia major, one target disease for its clinical application. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Finland | 1 | 3% |
Unknown | 33 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 24% |
Student > Master | 7 | 21% |
Student > Bachelor | 3 | 9% |
Student > Doctoral Student | 3 | 9% |
Student > Ph. D. Student | 3 | 9% |
Other | 6 | 18% |
Unknown | 4 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 29% |
Agricultural and Biological Sciences | 8 | 24% |
Biochemistry, Genetics and Molecular Biology | 6 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Other | 3 | 9% |
Unknown | 5 | 15% |