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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Large-scale production and protein engineering of G protein-coupled receptors for structural studies
|
|---|---|
| Published in |
Frontiers in Pharmacology, March 2015
|
| DOI | 10.3389/fphar.2015.00066 |
| Pubmed ID | |
| Authors |
Dalibor Milić, Dmitry B. Veprintsev |
| Abstract |
Structural studies of G protein-coupled receptors (GPCRs) gave insights into molecular mechanisms of their action and contributed significantly to molecular pharmacology. This is primarily due to technical advances in protein engineering, production and crystallization of these important receptor targets. On the other hand, NMR spectroscopy of GPCRs, which can provide information about their dynamics, still remains challenging due to difficulties in preparation of isotopically labeled receptors and their low long-term stabilities. In this review, we discuss methods used for expression and purification of GPCRs for crystallographic and NMR studies. We also summarize protein engineering methods that played a crucial role in obtaining GPCR crystal structures. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 247 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 2 | <1% |
| Switzerland | 1 | <1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 241 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 61 | 25% |
| Researcher | 48 | 19% |
| Student > Bachelor | 36 | 15% |
| Student > Master | 35 | 14% |
| Other | 8 | 3% |
| Other | 22 | 9% |
| Unknown | 37 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 99 | 40% |
| Agricultural and Biological Sciences | 60 | 24% |
| Chemistry | 21 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 3% |
| Engineering | 5 | 2% |
| Other | 17 | 7% |
| Unknown | 37 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2015.
All research outputs
#7,212,612
of 22,797,621 outputs
Outputs from Frontiers in Pharmacology
#3,020
of 16,015 outputs
Outputs of similar age
#86,387
of 264,714 outputs
Outputs of similar age from Frontiers in Pharmacology
#22
of 79 outputs
Altmetric has tracked 22,797,621 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 16,015 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,714 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.