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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Multi-target pharmacology: possibilities and limitations of the “skeleton key approach” from a medicinal chemist perspective
|
|---|---|
| Published in |
Frontiers in Pharmacology, September 2015
|
| DOI | 10.3389/fphar.2015.00205 |
| Pubmed ID | |
| Authors |
Alan Talevi |
| Abstract |
Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning to treat comorbid conditions is an additional, overlooked application of multi-target ligands. While medicinal chemists usually rely on some version of the lock and key paradigm to design novel therapeutics, modern pharmacology recognizes that the mid- and long-term effects of a given drug on a biological system may depend not only on the specific ligand-target recognition events but also on the influence of the repeated administration of a drug on the cell gene signature. The design of multi-target agents usually imposes challenging restrictions on the topology or flexibility of the candidate drugs, which are briefly discussed in the present article. Finally, computational strategies to approach the identification of novel multi-target agents are overviewed. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 295 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | 1% |
| South Africa | 1 | <1% |
| Unknown | 291 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 57 | 19% |
| Student > Master | 42 | 14% |
| Student > Bachelor | 39 | 13% |
| Researcher | 37 | 13% |
| Other | 10 | 3% |
| Other | 39 | 13% |
| Unknown | 71 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 60 | 20% |
| Biochemistry, Genetics and Molecular Biology | 47 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 33 | 11% |
| Agricultural and Biological Sciences | 23 | 8% |
| Medicine and Dentistry | 14 | 5% |
| Other | 20 | 7% |
| Unknown | 98 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2021.
All research outputs
#2,430,510
of 25,473,687 outputs
Outputs from Frontiers in Pharmacology
#1,017
of 19,829 outputs
Outputs of similar age
#32,272
of 286,202 outputs
Outputs of similar age from Frontiers in Pharmacology
#12
of 98 outputs
Altmetric has tracked 25,473,687 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 19,829 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,202 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.