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X Demographics
Mendeley readers
Attention Score in Context
| Title |
β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease
|
|---|---|
| Published in |
Frontiers in Pharmacology, September 2015
|
| DOI | 10.3389/fphar.2015.00221 |
| Pubmed ID | |
| Authors |
Xiaojuan Sun, Wei-Dong Chen, Yan-Dong Wang |
| Abstract |
The amyloid β peptide (Aβ) is a critical initiator that triggers the progression of Alzheimer's Disease (AD) via accumulation and aggregation, of which the process may be caused by Aβ overproduction or perturbation clearance. Aβ is generated from amyloid precursor protein through sequential cleavage of β- and γ-secretases while Aβ removal is dependent on the proteolysis and lysosome degradation system. Here, we overviewed the biogenesis and toxicity of Aβ as well as the regulation of Aβ production and clearance. Moreover, we also summarized the animal models correlated with Aβ that are essential in AD research. In addition, we discussed current immunotherapeutic approaches targeting Aβ to give some clues for exploring the more potentially efficient drugs for treatment of AD. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Switzerland | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 491 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | <1% |
| Israel | 1 | <1% |
| India | 1 | <1% |
| Greece | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 486 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 82 | 17% |
| Student > Ph. D. Student | 80 | 16% |
| Student > Master | 49 | 10% |
| Researcher | 31 | 6% |
| Student > Doctoral Student | 13 | 3% |
| Other | 52 | 11% |
| Unknown | 184 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 69 | 14% |
| Agricultural and Biological Sciences | 42 | 9% |
| Neuroscience | 38 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 35 | 7% |
| Medicine and Dentistry | 33 | 7% |
| Other | 67 | 14% |
| Unknown | 207 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 116. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2024.
All research outputs
#356,715
of 25,287,709 outputs
Outputs from Frontiers in Pharmacology
#132
of 19,500 outputs
Outputs of similar age
#4,713
of 281,104 outputs
Outputs of similar age from Frontiers in Pharmacology
#2
of 104 outputs
Altmetric has tracked 25,287,709 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 19,500 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,104 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.