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X Demographics
Mendeley readers
Attention Score in Context
| Title |
HDL as a drug and nucleic acid delivery vehicle
|
|---|---|
| Published in |
Frontiers in Pharmacology, October 2015
|
| DOI | 10.3389/fphar.2015.00247 |
| Pubmed ID | |
| Authors |
Andras G. Lacko, Nirupama A. Sabnis, Bhavani Nagarajan, Walter J. McConathy |
| Abstract |
This review is intended to evaluate the research findings and potential clinical applications of drug transport systems, developed based on the concepts of the structure/function and physiological role(s) of high density lipoprotein type nanoparticles. These macromolecules provide targeted transport of cholesteryl esters (a highly lipophilic payload) in their natural/physiological environment. The ability to accommodate highly water insoluble constituents in their core regions enables High density lipoproteins (HDL) type nanoparticles to effectively transport hydrophobic drugs subsequent to systemic administration. Even though the application of reconstituted HDL in the treatment of a number of diseases is reviewed, the primary focus is on the application of HDL type drug delivery agents in cancer chemotherapy. The use of both native and synthetic HDL as drug delivery agents is compared to evaluate their respective potentials for commercial and clinical development. The current status and future perspectives for HDL type nanoparticles are discussed, including current obstacles and future applications in therapeutics. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 70 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 19% |
| Student > Ph. D. Student | 12 | 17% |
| Student > Master | 8 | 11% |
| Researcher | 7 | 10% |
| Student > Doctoral Student | 6 | 9% |
| Other | 5 | 7% |
| Unknown | 19 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 26% |
| Medicine and Dentistry | 10 | 14% |
| Chemistry | 10 | 14% |
| Engineering | 4 | 6% |
| Agricultural and Biological Sciences | 4 | 6% |
| Other | 4 | 6% |
| Unknown | 20 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2016.
All research outputs
#18,429,829
of 22,831,537 outputs
Outputs from Frontiers in Pharmacology
#8,234
of 16,070 outputs
Outputs of similar age
#204,669
of 284,375 outputs
Outputs of similar age from Frontiers in Pharmacology
#57
of 97 outputs
Altmetric has tracked 22,831,537 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 16,070 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,375 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.