Yishu Yan, Changge Guan, Shanshan Du, Wenming Zhu, Yang Ji, Nan Su, Xiang Mei, Dong He, Yuan Lu, Chong Zhang, Xin-Hui Xing
Abstract
With regard to identifying the effective components of LMWH drugs curing hepatic fibrosis disease, we carried out a comparative study on the efficacy of enzymatically depolymerized LMWHs on CCl4 induced mouse liver fibrosis. The results showed that the controlled enzymatic depolymerization conditions resulted in LMWHs with significantly different activities. The LMWH product depolymerized by Heparinase I (I-11) with a Mw of 7160, exhibited a significant advantage in reducing the liver inflammation by suppressing TNF-α and IL-1β secretion, and minimizing hepatic fibrogenesis. The products prepared by only Heparinase II (II-11), and combined Heparinase III and II (III-II-5) showed limited positive effect on hepatic inflammation and fibrosis. On the contrary, the products by combined Heparinase III and I (III-I-9, III-I-5) showed no effect or stimulation effect on the hepatic fibrogenesis. Our results provided the basis for structure-activity relationship insight for inhibition of liver fibrosis activities of LMWHs, which might have significant implications for generic anti-fibrosis disease drug development.
Pharmacology, Toxicology and Pharmaceutical Science
1
8%
Other
2
15%
Unknown
4
31%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2017.
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#20,444,703
of 22,999,744 outputs
Outputs from Frontiers in Pharmacology
#10,193
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Outputs of similar age
#277,335
of 317,628 outputs
Outputs of similar age from Frontiers in Pharmacology
#157
of 249 outputs
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