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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
|
|---|---|
| Published in |
Frontiers in Pharmacology, February 2018
|
| DOI | 10.3389/fphar.2018.00104 |
| Pubmed ID | |
| Authors |
Shao-Ru Chen, Yan Dai, Jing Zhao, Ligen Lin, Yitao Wang, Ying Wang |
| Abstract |
Triptolide and celastrol are predominantly active natural products isolated from the medicinal plantTripterygium wilfordiiHook F. These compounds exhibit similar pharmacological activities, including anti-cancer, anti-inflammation, anti-obesity, and anti-diabetic activities. Triptolide and celastrol also provide neuroprotection and prevent cardiovascular and metabolic diseases. However, toxicity restricts the further development of triptolide and celastrol. In this review, we comprehensively review therapeutic targets and mechanisms of action, and translational study of triptolide and celastrol. We systemically discuss the structure-activity-relationship of triptolide, celastrol, and their derivatives. Furthermore, we propose the use of structural derivatives, targeted therapy, and combination treatment as possible solutions to reduce toxicity and increase therapeutic window of these potent natural products fromT. wilfordiiHook F. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 131 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 20 | 15% |
| Student > Master | 17 | 13% |
| Researcher | 14 | 11% |
| Student > Ph. D. Student | 13 | 10% |
| Student > Postgraduate | 5 | 4% |
| Other | 11 | 8% |
| Unknown | 51 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 25 | 19% |
| Biochemistry, Genetics and Molecular Biology | 18 | 14% |
| Medicine and Dentistry | 7 | 5% |
| Agricultural and Biological Sciences | 7 | 5% |
| Immunology and Microbiology | 6 | 5% |
| Other | 12 | 9% |
| Unknown | 56 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2019.
All research outputs
#20,015,146
of 25,461,852 outputs
Outputs from Frontiers in Pharmacology
#8,479
of 19,812 outputs
Outputs of similar age
#330,621
of 455,827 outputs
Outputs of similar age from Frontiers in Pharmacology
#152
of 318 outputs
Altmetric has tracked 25,461,852 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 19,812 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 455,827 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 318 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.