Title |
The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions
|
---|---|
Published in |
Frontiers in Pharmacology, April 2018
|
DOI | 10.3389/fphar.2018.00341 |
Pubmed ID | |
Authors |
Sabina Janciauskiene, Sabine Wrenger, Stephan Immenschuh, Beata Olejnicka, Timm Greulich, Tobias Welte, Joanna Chorostowska-Wynimko |
Abstract |
Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is one of the potent regulators of neutrophil activation via both -protease inhibitory and non-inhibitory functions. This review summarizes our current understanding of the effects of AAT on neutrophils, illustrating the interplay between AAT and the key effector functions of neutrophils. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 5 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 134 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 20 | 15% |
Researcher | 18 | 13% |
Student > Ph. D. Student | 17 | 13% |
Student > Master | 14 | 10% |
Student > Doctoral Student | 9 | 7% |
Other | 11 | 8% |
Unknown | 45 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 25 | 19% |
Medicine and Dentistry | 16 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 10% |
Agricultural and Biological Sciences | 10 | 7% |
Immunology and Microbiology | 6 | 4% |
Other | 13 | 10% |
Unknown | 51 | 38% |