Title |
A Review on the Effect of Traditional Chinese Medicine Against Anthracycline-Induced Cardiac Toxicity
|
---|---|
Published in |
Frontiers in Pharmacology, May 2018
|
DOI | 10.3389/fphar.2018.00444 |
Pubmed ID | |
Authors |
Xinyu Yang, Nian Liu, Xinye Li, Yihan Yang, Xiaofeng Wang, Linling Li, Le Jiang, Yonghong Gao, Hebin Tang, Yong Tang, Yanwei Xing, Hongcai Shang |
Abstract |
Anthracyclines are effective agents generally used to treat solid-tumor and hematologic malignancies. The use of anthracyclines for over 40 years has improved cancer survival statistics. Nevertheless, the clinical utility of anthracyclines is limited by its dose-dependent cardiotoxicity that adversely affects 10-30% of patients. Anthracycline-induced cardiotoxicity may be classified as acute/subacute or chronic/late toxicity and leads to devastating adverse effects resulting in poor quality of life, morbidity, and premature mortality. Traditional Chinese medicine has a history of over 2,000 years, involving both unique theories and substantial experience. Several studies have investigated the potential of natural products to decrease the cardiotoxic effects of chemotherapeutic agents on healthy cells, without negatively affecting their antineoplastic activity. This article discusses the mechanism of anthracycline-induced cardiotoxicity, and summarizes traditional Chinese medicine treatment for anthracycline-induced heart failure (HF), cardiac arrhythmia, cardiomyopathy, and myocardial ischemia in recent years, in order to provide a reference for the clinical prevention and treatment of cardiac toxicity. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 3 | 12% |
Student > Bachelor | 2 | 8% |
Student > Doctoral Student | 2 | 8% |
Student > Ph. D. Student | 2 | 8% |
Lecturer | 1 | 4% |
Other | 4 | 15% |
Unknown | 12 | 46% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 19% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 12% |
Chemistry | 3 | 12% |
Agricultural and Biological Sciences | 1 | 4% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Other | 2 | 8% |
Unknown | 11 | 42% |