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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Role of Necroptosis in Cardiovascular Disease
|
|---|---|
| Published in |
Frontiers in Pharmacology, July 2018
|
| DOI | 10.3389/fphar.2018.00721 |
| Pubmed ID | |
| Authors |
Shi Zhe-Wei, Ge Li-Sha, Li Yue-Chun |
| Abstract |
A newly discovered mechanism of cell death, programmed necrosis (necroptosis), combines features of both necrosis and apoptosis. Necroptosis is tightly modulated by a series of characteristic signaling pathways. Activating necroptosis by ligands of death receptors requires the kinase activity of receptor-interacting protein 1 (RIP1), which mediates the activation of receptor-interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) two critical downstream mediators of necroptosis. Recently, different cytokines have been found participating in this mechanism of cell death. Necroptosis has been proposed as an important component to the pathophysiology of heart disease such as vascular atherosclerosis, ischemia-reperfusion injury, myocardial infarction and cardiac remodeling. Targeting necroptosis signaling pathways may provide therapeutic benefit in the treatment of cardiovascular diseases. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 86 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 17% |
| Student > Ph. D. Student | 14 | 16% |
| Student > Master | 6 | 7% |
| Researcher | 5 | 6% |
| Student > Doctoral Student | 4 | 5% |
| Other | 13 | 15% |
| Unknown | 29 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 25 | 29% |
| Medicine and Dentistry | 10 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 10% |
| Agricultural and Biological Sciences | 6 | 7% |
| Immunology and Microbiology | 3 | 3% |
| Other | 4 | 5% |
| Unknown | 29 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2018.
All research outputs
#6,895,159
of 23,096,849 outputs
Outputs from Frontiers in Pharmacology
#2,844
of 16,456 outputs
Outputs of similar age
#117,560
of 327,719 outputs
Outputs of similar age from Frontiers in Pharmacology
#69
of 399 outputs
Altmetric has tracked 23,096,849 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 16,456 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,719 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 399 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.