Natalia Elfimova, Martin Schlattjan, Jan-Peter Sowa, Hans Peter Dienes, Ali Canbay, Margarete Odenthal
Abstract
Acute liver failure as life threatening condition comprises a difficult diagnostic situation to evaluate potential outcomes and therapeutic options. Thus, prognostic indicators are urgently needed for evaluation of progression of liver injury, clinical outcome, prognosis, and for therapeutic response. Recently, circulating microRNA, in particular miR-122, was described as a potential biomarker of acute liver injury after intoxication of mice. Circulating microRNA (miRNA) molecules are very stable and RNase-resistant due to protein aggregation and vesicle enclosure. Since miRNA species are known to be associated with chronic liver damage or with liver cancer, circulating miRNA patterns are suggested to serve also as reporters for progression of acute liver failure. miRNA profiling analyses using PCR arrays or next generation sequencing, may achieve identification of miRNA species that are linked to the rapid progression of acute liver injury, to the outcome of liver failure, or to the therapeutic response. Therefore, circulating miRNAs are promising, non-invasive biomarkers of future diagnostic approaches. However, normalisation of circulating miRNA levels is essential and further standardisation of miRNA quantification assays is needed.
Pharmacology, Toxicology and Pharmaceutical Science
2
5%
Other
6
16%
Unknown
5
13%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2012.
All research outputs
#20,176,348
of 22,689,790 outputs
Outputs from Frontiers in Physiology
#9,283
of 13,486 outputs
Outputs of similar age
#221,229
of 244,142 outputs
Outputs of similar age from Frontiers in Physiology
#208
of 309 outputs
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