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Association of heart rate variability and inflammatory response in patients with cardiovascular diseases: current strengths and limitations

Overview of attention for article published in Frontiers in Physiology, January 2013
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

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1 blog
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Title
Association of heart rate variability and inflammatory response in patients with cardiovascular diseases: current strengths and limitations
Published in
Frontiers in Physiology, January 2013
DOI 10.3389/fphys.2013.00174
Pubmed ID
Authors

Vasilios Papaioannou, Ioannis Pneumatikos, Nikos Maglaveras

Abstract

Many experimental and clinical studies have confirmed a continuous cross-talk between both sympathetic and parasympathetic branches of autonomic nervous system and inflammatory response, in different clinical scenarios. In cardiovascular diseases, inflammation has been proven to play a pivotal role in disease progression, pathogenesis and resolution. A few clinical studies have assessed the possible inter-relation between neuro-autonomic output, estimated with heart rate variability analysis, which is the variability of R-R in the electrocardiogram, and different inflammatory biomarkers, in patients suffering from stable or unstable coronary artery disease (CAD) and heart failure. Moreover, different indices derived from heart rate signals' processing, have been proven to correlate strongly with severity of heart disease and predict final outcome. In this review article we will summarize major findings from different investigators, evaluating neuro-immunological interactions through heart rate variability analysis, in different groups of cardiovascular patients. We suggest that markers originating from variability analysis of heart rate signals seem to be related to inflammatory biomarkers. However, a lot of open questions remain to be addressed, regarding the existence of a true association between heart rate variability and autonomic nervous system output or its adoption for risk stratification and therapeutic monitoring at the bedside. Finally, potential therapeutic implications will be discussed, leading to autonomic balance restoration in relation with inflammatory control.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Netherlands 1 <1%
United Kingdom 1 <1%
New Zealand 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 123 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 20%
Student > Master 14 11%
Student > Bachelor 13 10%
Researcher 11 9%
Student > Doctoral Student 10 8%
Other 34 26%
Unknown 21 16%
Readers by discipline Count As %
Medicine and Dentistry 44 34%
Agricultural and Biological Sciences 10 8%
Engineering 8 6%
Psychology 6 5%
Sports and Recreations 5 4%
Other 20 16%
Unknown 36 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2014.
All research outputs
#4,087,640
of 22,713,403 outputs
Outputs from Frontiers in Physiology
#2,080
of 13,524 outputs
Outputs of similar age
#43,563
of 280,747 outputs
Outputs of similar age from Frontiers in Physiology
#66
of 398 outputs
Altmetric has tracked 22,713,403 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,524 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,747 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 398 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.