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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Alcohol modulation of G-protein-gated inwardly rectifying potassium channels: from binding to therapeutics
|
|---|---|
| Published in |
Frontiers in Physiology, January 2014
|
| DOI | 10.3389/fphys.2014.00076 |
| Pubmed ID | |
| Authors |
Karthik Bodhinathan, Paul A. Slesinger |
| Abstract |
Alcohol (ethanol)-induced behaviors may arise from direct interaction of alcohol with discrete protein cavities within brain proteins. Recent structural and biochemical studies have provided new insights into the mechanism of alcohol-dependent activation of G protein-gated inwardly rectifying potassium (GIRK) channels, which regulate neuronal responses in the brain reward circuit. GIRK channels contain an alcohol binding pocket formed at the interface of two adjacent channel subunits. Here, we discuss the physiochemical properties of the alcohol pocket and the roles of G protein βγ subunits and membrane phospholipid PIP2 in regulating the alcohol response of GIRK channels. Some of the features of alcohol modulation of GIRK channels may be common to other alcohol-sensitive brain proteins. We discuss the possibility of alcohol-selective therapeutics that block alcohol access to the pocket. Understanding alcohol recognition and modulation of brain proteins is essential for development of therapeutics for alcohol abuse and addiction. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 40% |
| Scientists | 1 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 46 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 29% |
| Researcher | 9 | 19% |
| Student > Bachelor | 6 | 13% |
| Student > Master | 5 | 10% |
| Professor | 4 | 8% |
| Other | 5 | 10% |
| Unknown | 5 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 25% |
| Biochemistry, Genetics and Molecular Biology | 8 | 17% |
| Neuroscience | 7 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
| Medicine and Dentistry | 3 | 6% |
| Other | 5 | 10% |
| Unknown | 9 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2015.
All research outputs
#12,894,736
of 22,745,803 outputs
Outputs from Frontiers in Physiology
#4,093
of 13,552 outputs
Outputs of similar age
#156,692
of 305,224 outputs
Outputs of similar age from Frontiers in Physiology
#47
of 106 outputs
Altmetric has tracked 22,745,803 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,552 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,224 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.