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Mendeley readers
Attention Score in Context
| Title |
PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating
|
|---|---|
| Published in |
Frontiers in Physiology, May 2014
|
| DOI | 10.3389/fphys.2014.00195 |
| Pubmed ID | |
| Authors |
Mark A. Zaydman, Jianmin Cui |
| Abstract |
Voltage-gated potassium (Kv) channels contain voltage-sensing (VSD) and pore-gate (PGD) structural domains. During voltage-dependent gating, conformational changes in the two domains are coupled giving rise to voltage-dependent opening of the channel. In addition to membrane voltage, KCNQ (Kv7) channel opening requires the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2). Recent studies suggest that PIP2 serves as a cofactor to mediate VSD-PGD coupling in KCNQ1 channels. In this review, we put these findings in the context of the current understanding of voltage-dependent gating, lipid modulation of Kv channel activation, and PIP2-regulation of KCNQ channels. We suggest that lipid-mediated coupling of functional domains is a common mechanism among KCNQ channels that may be applicable to other Kv channels and membrane proteins. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 2 | 2% |
| Germany | 1 | <1% |
| Belgium | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 108 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 19% |
| Researcher | 17 | 15% |
| Student > Bachelor | 15 | 13% |
| Student > Doctoral Student | 12 | 11% |
| Student > Master | 10 | 9% |
| Other | 15 | 13% |
| Unknown | 23 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 26% |
| Biochemistry, Genetics and Molecular Biology | 21 | 18% |
| Medicine and Dentistry | 13 | 11% |
| Neuroscience | 12 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Other | 11 | 10% |
| Unknown | 21 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2014.
All research outputs
#20,230,558
of 22,756,196 outputs
Outputs from Frontiers in Physiology
#9,328
of 13,559 outputs
Outputs of similar age
#191,967
of 226,570 outputs
Outputs of similar age from Frontiers in Physiology
#75
of 106 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,559 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,570 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.