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X Demographics
Mendeley readers
Attention Score in Context
| Title |
3D hydrogel environment rejuvenates aged pericytes for skeletal muscle tissue engineering
|
|---|---|
| Published in |
Frontiers in Physiology, May 2014
|
| DOI | 10.3389/fphys.2014.00203 |
| Pubmed ID | |
| Authors |
Claudia Fuoco, Elena Sangalli, Rosa Vono, Stefano Testa, Benedetto Sacchetti, Michael V. G. Latronico, Sergio Bernardini, Paolo Madeddu, Gianni Cesareni, Dror Seliktar, Roberto Rizzi, Claudia Bearzi, Stefano M. Cannata, Gaia Spinetti, Cesare Gargioli |
| Abstract |
Skeletal muscle tissue engineering is a promising approach for the treatment of muscular disorders. However, the complex organization of muscle, combined with the difficulty in finding an appropriate source of regenerative cells and in providing an adequate blood supply to the engineered tissue, makes this a hard task to face. In the present work, we describe an innovative approach to rejuvenate adult skeletal muscle-derived pericytes (MP) based on the use of a PEG-based hydrogel scaffold. MP were isolated from young (piglet) and adult (boar) pigs to assess whether aging affects tissue regeneration efficiency. In vitro, MP from boars had similar morphology and colony forming capacity to piglet MP, but an impaired ability to form myotubes and capillary-like structures. However, the use of a PEG-based hydrogel to support adult MP significantly improved their myogenic differentiation and angiogenic potentials in vitro and in vivo. Thus, PEG-based hydrogel scaffolds may provide a progenitor cell "niche" that promotes skeletal muscle regeneration and blood vessel growth, and together with pericytes may be developed for use in regenerative applications. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Portugal | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 124 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 21% |
| Student > Master | 20 | 16% |
| Researcher | 16 | 13% |
| Student > Bachelor | 10 | 8% |
| Professor | 8 | 6% |
| Other | 22 | 17% |
| Unknown | 24 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 20% |
| Engineering | 21 | 17% |
| Biochemistry, Genetics and Molecular Biology | 16 | 13% |
| Medicine and Dentistry | 13 | 10% |
| Materials Science | 5 | 4% |
| Other | 18 | 14% |
| Unknown | 29 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2016.
All research outputs
#17,721,395
of 22,756,196 outputs
Outputs from Frontiers in Physiology
#7,113
of 13,559 outputs
Outputs of similar age
#155,148
of 226,629 outputs
Outputs of similar age from Frontiers in Physiology
#60
of 107 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,559 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,629 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.