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Potential of caveolae in the therapy of cardiovascular and neurological diseases

Overview of attention for article published in Frontiers in Physiology, September 2014
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  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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Title
Potential of caveolae in the therapy of cardiovascular and neurological diseases
Published in
Frontiers in Physiology, September 2014
DOI 10.3389/fphys.2014.00370
Pubmed ID
Authors

Gemma Navarro, Dasiel O. Borroto-Escuela, Kjell Fuxe, Rafael Franco

Abstract

Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
United Kingdom 1 2%
Spain 1 2%
Malaysia 1 2%
Unknown 48 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 23%
Student > Ph. D. Student 10 19%
Student > Doctoral Student 5 9%
Professor 5 9%
Student > Postgraduate 5 9%
Other 11 21%
Unknown 5 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 30%
Biochemistry, Genetics and Molecular Biology 7 13%
Neuroscience 7 13%
Medicine and Dentistry 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 9 17%
Unknown 9 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2015.
All research outputs
#14,786,597
of 22,765,347 outputs
Outputs from Frontiers in Physiology
#5,653
of 13,560 outputs
Outputs of similar age
#139,351
of 252,706 outputs
Outputs of similar age from Frontiers in Physiology
#40
of 125 outputs
Altmetric has tracked 22,765,347 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,560 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,706 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.