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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Oxidative stress-mediated HMGB1 biology
|
|---|---|
| Published in |
Frontiers in Physiology, April 2015
|
| DOI | 10.3389/fphys.2015.00093 |
| Pubmed ID | |
| Authors |
Yan Yu, Daolin Tang, Rui Kang |
| Abstract |
High mobility group box 1 (HMGB1) is a widely-expressed and highly-abundant protein that acts as an extracellular signal upon active secretion by immune cells or passive release by dead, dying, and injured cells. Both intracellular and extracellular HMGB1 play pivotal roles in regulation of the cellular response to stress. Targeting the translocation, release, and activity of HMGB1 can limit inflammation and reduce tissue damage during infection and sterile inflammation. Although the mechanisms contributing to HMGB1 biology are still under investigation, it appears that oxidative stress is a central regulator of HMGB1's translocation, release, and activity in inflammation and cell death (e.g., necrosis, apoptosis, autophagic cell death, pyroptosis, and NETosis). Thus, targeting HMGB1 with antioxidant compounds may be an attractive therapeutic strategy for inflammation-associated diseases such as sepsis, ischemia and reperfusion injury, arthritis, diabetes, and cancer. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 155 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 22% |
| Researcher | 24 | 15% |
| Student > Bachelor | 14 | 9% |
| Student > Master | 13 | 8% |
| Student > Doctoral Student | 12 | 8% |
| Other | 30 | 19% |
| Unknown | 28 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 27% |
| Biochemistry, Genetics and Molecular Biology | 35 | 22% |
| Agricultural and Biological Sciences | 17 | 11% |
| Immunology and Microbiology | 10 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
| Other | 12 | 8% |
| Unknown | 32 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2024.
All research outputs
#7,227,677
of 25,436,226 outputs
Outputs from Frontiers in Physiology
#3,393
of 15,656 outputs
Outputs of similar age
#80,314
of 280,110 outputs
Outputs of similar age from Frontiers in Physiology
#18
of 109 outputs
Altmetric has tracked 25,436,226 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 15,656 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,110 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.