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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Role of bone morphogenetic protein-7 in renal fibrosis
|
|---|---|
| Published in |
Frontiers in Physiology, April 2015
|
| DOI | 10.3389/fphys.2015.00114 |
| Pubmed ID | |
| Authors |
Rui Xi Li, Wai Han Yiu, Sydney C. W. Tang |
| Abstract |
Renal fibrosis is final common pathway of end stage renal disease. Irrespective of the primary cause, renal fibrogenesis is a dynamic process which involves a large network of cellular and molecular interaction, including pro-inflammatory cell infiltration and activation, matrix-producing cell accumulation and activation, and secretion of profibrogenic factors that modulate extracellular matrix (ECM) formation and cell-cell interaction. Bone morphogenetic protein-7 is a protein of the TGF-β super family and increasingly regarded as a counteracting molecule against TGF-β. A large variety of evidence shows an anti-fibrotic role of BMP-7 in chronic kidney disease, and this effect is largely mediated via counterbalancing the profibrotic effect of TGF-β. Besides, BMP-7 reduced ECM formation by inactivating matrix-producing cells and promoting mesenchymal-to-epithelial transition (MET). BMP-7 also increased ECM degradation. Despite these observations, the anti-fibrotic effect of BMP-7 is still controversial such that fine regulation of BMP-7 expression in vivo might be a great challenge for its ultimate clinical application. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 29% |
| Researcher | 9 | 18% |
| Student > Master | 5 | 10% |
| Professor > Associate Professor | 4 | 8% |
| Student > Bachelor | 4 | 8% |
| Other | 7 | 14% |
| Unknown | 6 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 31% |
| Agricultural and Biological Sciences | 12 | 24% |
| Biochemistry, Genetics and Molecular Biology | 7 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
| Business, Management and Accounting | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 7 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2015.
All research outputs
#20,269,439
of 22,800,560 outputs
Outputs from Frontiers in Physiology
#9,349
of 13,562 outputs
Outputs of similar age
#223,876
of 265,382 outputs
Outputs of similar age from Frontiers in Physiology
#71
of 104 outputs
Altmetric has tracked 22,800,560 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,562 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,382 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.