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Malformations of the tooth root in humans

Overview of attention for article published in Frontiers in Physiology, October 2015
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Title
Malformations of the tooth root in humans
Published in
Frontiers in Physiology, October 2015
DOI 10.3389/fphys.2015.00307
Pubmed ID
Authors

Hans U. Luder

Abstract

The most common root malformations in humans arise from either developmental disorders of the root alone or disorders of radicular development as part of a general tooth dysplasia. The aim of this review is to relate the characteristics of these root malformations to potentially disrupted processes involved in radicular morphogenesis. Radicular morphogenesis proceeds under the control of Hertwig's epithelial root sheath (HERS) which determines the number, length, and shape of the root, induces the formation of radicular dentin, and participates in the development of root cementum. Formation of HERS at the transition from crown to root development appears to be very insensitive to adverse effects, with the result that rootless teeth are extremely rare. In contrast, shortened roots as a consequence of impaired or prematurely halted apical growth of HERS constitute the most prevalent radicular dysplasia which occurs due to trauma and unknown reasons as well as in association with dentin disorders. While odontoblast differentiation inevitably stops when growth of HERS is arrested, it seems to be unaffected even in cases of severe dentin dysplasias such as regional odontodysplasia and dentin dysplasia type I. As a result radicular dentin formation is at least initiated and progresses for a limited time. The only condition affecting cementogenesis is hypophosphatasia which disrupts the formation of acellular cementum through an inhibition of mineralization. A process particularly susceptible to adverse effects appears to be the formation of the furcation in multirooted teeth. Impairment or disruption of this process entails taurodontism, single-rooted posterior teeth, and misshapen furcations. Thus, even though many characteristics of human root malformations can be related to disorders of specific processes involved in radicular morphogenesis, precise inferences as to the pathogenesis of these dysplasias are hampered by the still limited knowledge on root formation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Unknown 142 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 13%
Student > Bachelor 18 13%
Researcher 16 11%
Student > Postgraduate 16 11%
Student > Doctoral Student 8 6%
Other 24 17%
Unknown 43 30%
Readers by discipline Count As %
Medicine and Dentistry 72 50%
Biochemistry, Genetics and Molecular Biology 8 6%
Agricultural and Biological Sciences 3 2%
Psychology 3 2%
Engineering 2 1%
Other 8 6%
Unknown 47 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2015.
All research outputs
#20,295,099
of 22,831,537 outputs
Outputs from Frontiers in Physiology
#9,379
of 13,603 outputs
Outputs of similar age
#238,654
of 284,522 outputs
Outputs of similar age from Frontiers in Physiology
#88
of 113 outputs
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So far Altmetric has tracked 13,603 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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