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Candida albicans and Pseudomonas aeruginosa Interaction, with Focus on the Role of Eicosanoids

Overview of attention for article published in Frontiers in Physiology, February 2016
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  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

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146 Mendeley
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Title
Candida albicans and Pseudomonas aeruginosa Interaction, with Focus on the Role of Eicosanoids
Published in
Frontiers in Physiology, February 2016
DOI 10.3389/fphys.2016.00064
Pubmed ID
Authors

Ruan Fourie, Ruan Ells, Chantel W. Swart, Olihile M. Sebolai, Jacobus Albertyn, Carolina H. Pohl

Abstract

Candida albicans is commonly found in mixed infections with Pseudomonas aeruginosa, especially in the lungs of cystic fibrosis (CF) patients. Both of these opportunistic pathogens are able to form resistant biofilms and frequently infect immunocompromised individuals. The interaction between these two pathogens, which includes physical interaction as well as secreted factors, is mainly antagonistic. In addition, research suggests considerable interaction with their host, especially with immunomodulatory lipid mediators, termed eicosanoids. Candida albicans and Pseudomonas aeruginosa are both able to utilize arachidonic acid (AA), liberated from the host cells during infection, to form eicosanoids. The production of these eicosanoids, such as Prostaglandin E2, by the host and the pathogens may affect the dynamics of polymicrobial infection and the outcome of infections. It is of considerable importance to elucidate the role of host-produced, as well as pathogen-produced eicosanoids in polymicrobial infection. This review will focus on in vitro as well as in vivo interaction between C. albicans and P. aeruginosa, paying special attention to the role of eicosanoids in the cross-talk between host and the pathogens.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 145 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 16%
Researcher 18 12%
Student > Master 17 12%
Student > Bachelor 16 11%
Student > Postgraduate 12 8%
Other 23 16%
Unknown 37 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 21%
Immunology and Microbiology 24 16%
Biochemistry, Genetics and Molecular Biology 21 14%
Medicine and Dentistry 8 5%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Other 14 10%
Unknown 43 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2016.
All research outputs
#13,459,901
of 22,852,911 outputs
Outputs from Frontiers in Physiology
#4,683
of 13,641 outputs
Outputs of similar age
#142,956
of 297,860 outputs
Outputs of similar age from Frontiers in Physiology
#60
of 134 outputs
Altmetric has tracked 22,852,911 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,641 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,860 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 134 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.