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Cardiovascular Response Patterns to Sympathetic Stimulation by Central Hypovolemia

Overview of attention for article published in Frontiers in Physiology, June 2016
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Title
Cardiovascular Response Patterns to Sympathetic Stimulation by Central Hypovolemia
Published in
Frontiers in Physiology, June 2016
DOI 10.3389/fphys.2016.00235
Pubmed ID
Authors

Anne-Sophie G. T. Bronzwaer, Jasper Verbree, Wim J. Stok, Mark A. van Buchem, Mat J. A. P. Daemen, Matthias J. P. van Osch, Johannes. J. van Lieshout

Abstract

In healthy subjects, variation in cardiovascular responses to sympathetic stimulation evoked by submaximal lower body negative pressure (LBNP) is considerable. This study addressed the question whether inter-subject variation in cardiovascular responses coincides with consistent and reproducible responses in an individual subject. In 10 healthy subjects (5 female, median age 22 years), continuous hemodynamic parameters (finger plethysmography; Nexfin, Edwards Lifesciences), and time-domain baroreflex sensitivity (BRS) were quantified during three consecutive 5-min runs of LBNP at -50 mmHg. The protocol was repeated after 1 week to establish intra-subject reproducibility. In response to LBNP, 5 subjects (3 females) showed a prominent increase in heart rate (HR; 54 ± 14%, p = 0.001) with no change in total peripheral resistance (TPR; p = 0.25) whereas the other 5 subjects (2 females) demonstrated a significant rise in TPR (7 ± 3%, p = 0.017) with a moderate increase in HR (21 ± 9%, p = 0.004). These different reflex responses coincided with differences in resting BRS (22 ± 8 vs. 11 ± 3 ms/mmHg, p = 0.049) and resting HR (57 ± 8 vs. 71 ± 12 bpm, p = 0.047) and were highly reproducible over time. In conclusion, we found distinct cardiovascular response patterns to sympathetic stimulation by LBNP in young healthy individuals. These patterns of preferential autonomic blood pressure control appeared related to resting cardiac BRS and HR and were consistent over time.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 23%
Student > Master 5 19%
Researcher 3 12%
Student > Ph. D. Student 3 12%
Student > Doctoral Student 2 8%
Other 3 12%
Unknown 4 15%
Readers by discipline Count As %
Medicine and Dentistry 6 23%
Engineering 3 12%
Sports and Recreations 3 12%
Immunology and Microbiology 2 8%
Agricultural and Biological Sciences 2 8%
Other 8 31%
Unknown 2 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2016.
All research outputs
#20,333,181
of 22,877,793 outputs
Outputs from Frontiers in Physiology
#9,417
of 13,671 outputs
Outputs of similar age
#306,192
of 353,751 outputs
Outputs of similar age from Frontiers in Physiology
#119
of 171 outputs
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So far Altmetric has tracked 13,671 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 171 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.