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Modulation of Mammary Gland Development and Milk Production by Growth Hormone Expression in GH Transgenic Goats

Overview of attention for article published in Frontiers in Physiology, June 2016
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Title
Modulation of Mammary Gland Development and Milk Production by Growth Hormone Expression in GH Transgenic Goats
Published in
Frontiers in Physiology, June 2016
DOI 10.3389/fphys.2016.00278
Pubmed ID
Authors

Zekun Bao, Jian Lin, Lulu Ye, Qiang Zhang, Jianquan Chen, Qian Yang, Qinghua Yu

Abstract

Mammary gland development during puberty and reconstruction during pregnancy and lactation is under the control of circulating endocrine hormones, such as growth hormone, which are released from the pituitary. In this study, we explored the influence of overexpression of growth hormone in the mammary gland on breast development and milk production in goats. Using transcriptome sequencing, we found that the number of highly expressed genes was greater in GH transgenic goats than non-transgenic goats. Furthermore, KEGG pathway analysis showed that the majority of the genes belonged to the MAPK signaling pathway and the ECM-receptor interaction pathway. The expression of genes related to breast development was further confirmed using qRT-PCR. Interestingly, both milk production and milk quality were increased. The results of these experiments imply that overexpression of growth hormone in the breast may stimulate breast development and enhances milk production by modulating alveolar cell proliferation or branching through the MAPK signaling pathway.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 23%
Student > Bachelor 4 13%
Student > Doctoral Student 3 10%
Student > Postgraduate 2 7%
Researcher 2 7%
Other 2 7%
Unknown 10 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 20%
Veterinary Science and Veterinary Medicine 3 10%
Agricultural and Biological Sciences 3 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Business, Management and Accounting 1 3%
Other 2 7%
Unknown 13 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2016.
All research outputs
#18,464,797
of 22,880,230 outputs
Outputs from Frontiers in Physiology
#8,169
of 13,671 outputs
Outputs of similar age
#267,436
of 352,012 outputs
Outputs of similar age from Frontiers in Physiology
#95
of 171 outputs
Altmetric has tracked 22,880,230 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,671 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,012 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 171 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.