Title |
Roux-En Y Gastric Bypass Results in Long-Term Remission of Hepatocyte Apoptosis and Hepatic Histological Features of Non-alcoholic Steatohepatitis
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Published in |
Frontiers in Physiology, August 2016
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DOI | 10.3389/fphys.2016.00344 |
Pubmed ID | |
Authors |
Anne-Sophie Schneck, Rodolphe Anty, Stéphanie Patouraux, Stéphanie Bonnafous, Déborah Rousseau, Cynthia Lebeaupin, Beatrice Bailly-Maitre, Arnaud Sans, Albert Tran, Jean Gugenheim, Antonio Iannelli, Philippe Gual |
Abstract |
The long-term effects of bariatric surgery on non-alcoholic steatohepatitis (NASH), focusing on liver injury and hepatocyte apoptosis, are not well-established. We here performed a longitudinal study with paired liver biopsies of nine morbidly obese women (median BMI: 42 [38.7; 45.1] kg/m(2)) with NASH with a median follow-up of 55 [44; 75] months after laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery. LRYGB surgery was associated with significant weight loss (median BMI loss -13.7 [-16.4; -9.5] kg/m(2)), improved hepatic steatosis in all patients (55.5% with total resolution), and resolution of hepatic inflammation and hepatocyte ballooning in 100 and 88.8% of cases, respectively. Alanine aminotransferase levels dropped to normal values while hepatic activated cleaved caspase-3 levels strongly decreased after a median follow-up of 55 months. Hepatocyte apoptosis, as evaluated by serum caspase-generated keratin-18 fragment, improved within the first year following LRYGB and these improvements persisted for at least 55 months. LRYGB in morbidly obese patients with NASH is thus associated with a long-lasting beneficial impact on hepatic steatohepatitis and hepatocyte death. |
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Mexico | 1 | 33% |
Switzerland | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 6 | 14% |
Researcher | 5 | 11% |
Student > Bachelor | 5 | 11% |
Student > Postgraduate | 4 | 9% |
Student > Doctoral Student | 3 | 7% |
Other | 11 | 25% |
Unknown | 10 | 23% |
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Immunology and Microbiology | 3 | 7% |
Psychology | 2 | 5% |
Arts and Humanities | 1 | 2% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 7 | 16% |
Unknown | 12 | 27% |