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Mendeley readers
Attention Score in Context
| Title |
The Cu, Zn Superoxide Dismutase: Not Only a Dismutase Enzyme
|
|---|---|
| Published in |
Frontiers in Physiology, November 2016
|
| DOI | 10.3389/fphys.2016.00594 |
| Pubmed ID | |
| Authors |
Paolo Mondola, Simona Damiano, Anna Sasso, Mariarosaria Santillo |
| Abstract |
The Cu,Zn superoxide dismutase (SOD1) is an ubiquitary cytosolic dimeric carbohydrate free molecule, belonging to a family of isoenzymes involved in the scavenger of superoxide anions. This effect certainly represents the main and well known function ascribed to this enzyme. Here we highlight new aspects of SOD1 physiology that point out some inedited effects of this enzyme in addition to the canonic role of oxygen radical enzymatic dismutation. In the last two decades our research group produced many data obtained in in vitro studies performed in many cellular lines, mainly neuroblastoma SK-N-BE cells, indicating that this enzyme is secreted either constitutively or after depolarization induced by high extracellular K(+) concentration. In addition, we gave many experimental evidences showing that SOD1 is able to stimulate, through muscarinic M1 receptor, pathways involving ERK1/2, and AKT activation. These effects are accompanied with an intracellular calcium increase. In the last part of this review we describe researches that link deficient extracellular secretion of mutant SOD1(G93A) to its intracellular accumulation and toxicity in NSC-34 cells. Alternatively, SOD1(G93A) toxicity has been attributed to a decrease of Km for H2O2 with consequent OH radical formation. Interestingly, this last inedited effect of SOD1(G93A) could represent a gain of function that could be involved in the pathogenesis of familial Amyotrophic Lateral Sclerosis (fALS). |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 1% |
| Australia | 1 | <1% |
| Greece | 1 | <1% |
| Unknown | 169 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 29 | 17% |
| Student > Ph. D. Student | 22 | 13% |
| Researcher | 19 | 11% |
| Student > Master | 14 | 8% |
| Student > Postgraduate | 13 | 8% |
| Other | 28 | 16% |
| Unknown | 48 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 35 | 20% |
| Agricultural and Biological Sciences | 18 | 10% |
| Medicine and Dentistry | 17 | 10% |
| Chemistry | 11 | 6% |
| Neuroscience | 8 | 5% |
| Other | 34 | 20% |
| Unknown | 50 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2016.
All research outputs
#20,355,479
of 22,903,988 outputs
Outputs from Frontiers in Physiology
#9,425
of 13,694 outputs
Outputs of similar age
#350,489
of 416,538 outputs
Outputs of similar age from Frontiers in Physiology
#152
of 220 outputs
Altmetric has tracked 22,903,988 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,694 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,538 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 220 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.