Title |
Caveolae: A Role in Endothelial Inflammation and Mechanotransduction?
|
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Published in |
Frontiers in Physiology, December 2016
|
DOI | 10.3389/fphys.2016.00628 |
Pubmed ID | |
Authors |
Waled A. Shihata, Danielle L. Michell, Karen L. Andrews, Jaye P. F. Chin-Dusting |
Abstract |
Vascular inflammation and disease progression, such as atherosclerosis, are in part a consequence of haemodynamic forces generated by changes in blood flow. The haemodynamic forces, such as shear stress or stretch, interact with vascular endothelial cells, which transduce the mechanical stimuli into biochemical signals via mechanosensors, which can induce an upregulation in pathways involved in inflammatory signaling. However, it is unclear how these mechanosensors respond to shear stress and most significantly what cellular mechanisms are involved in sensing the haemodynamic stimuli. This review explores the transition from shear forces, stretch and pressure to endothelial inflammation and the process of mechanotransduction, specifically highlighting evidence to suggest that caveolae play as a role as mechanosensors. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 60 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 17% |
Student > Bachelor | 9 | 15% |
Researcher | 8 | 13% |
Student > Doctoral Student | 8 | 13% |
Student > Master | 7 | 12% |
Other | 9 | 15% |
Unknown | 9 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 20% |
Medicine and Dentistry | 8 | 13% |
Agricultural and Biological Sciences | 8 | 13% |
Engineering | 4 | 7% |
Chemistry | 2 | 3% |
Other | 7 | 12% |
Unknown | 19 | 32% |