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Orthostatic Intolerance in Older Persons: Etiology and Countermeasures

Overview of attention for article published in Frontiers in Physiology, November 2017
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Title
Orthostatic Intolerance in Older Persons: Etiology and Countermeasures
Published in
Frontiers in Physiology, November 2017
DOI 10.3389/fphys.2017.00803
Pubmed ID
Authors

Nandu Goswami, Andrew P. Blaber, Helmut Hinghofer-Szalkay, Jean-Pierre Montani

Abstract

Orthostatic challenge produced by upright posture may lead to syncope if the cardiovascular system is unable to maintain adequate brain perfusion. This review outlines orthostatic intolerance related to the aging process, long-term bedrest confinement, drugs, and disease. Aging-associated illness or injury due to falls often leads to hospitalization. Older patients spend up to 83% of hospital admission lying in bed and thus the consequences of bedrest confinement such as physiological deconditioning, functional decline, and orthostatic intolerance represent a central challenge in the care of the vulnerable older population. This review examines current scientific knowledge regarding orthostatic intolerance and how it comes about and provides a framework for understanding of (patho-) physiological concepts of cardiovascular (in-) stability in ambulatory and bedrest confined senior citizens as well as in individuals with disease conditions [e.g., orthostatic intolerance in patients with diabetes mellitus, multiple sclerosis, Parkinson's, spinal cord injury (SCI)] or those on multiple medications (polypharmacy). Understanding these aspects, along with cardio-postural interactions, is particularly important as blood pressure destabilization leading to orthostatic intolerance affects 3-4% of the general population, and in 4 out of 10 cases the exact cause remains elusive. Reviewed also are countermeasures to orthostatic intolerance such as exercise, water drinking, mental arithmetic, cognitive training, and respiration training in SCI patients. We speculate that optimally applied countermeasures such as mental challenge maintain sympathetic activity, and improve venous return, stroke volume, and consequently, blood pressure during upright standing. Finally, this paper emphasizes the importance of an active life style in old age and why early re-mobilization following bedrest confinement or bedrest is crucial in preventing orthostatic intolerance, falls and falls-related injuries in older persons.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 198 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 198 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 30 15%
Student > Ph. D. Student 25 13%
Student > Master 20 10%
Student > Doctoral Student 16 8%
Researcher 12 6%
Other 25 13%
Unknown 70 35%
Readers by discipline Count As %
Medicine and Dentistry 38 19%
Nursing and Health Professions 27 14%
Engineering 10 5%
Neuroscience 9 5%
Sports and Recreations 6 3%
Other 30 15%
Unknown 78 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2017.
All research outputs
#20,451,991
of 23,007,887 outputs
Outputs from Frontiers in Physiology
#9,478
of 13,760 outputs
Outputs of similar age
#288,681
of 331,178 outputs
Outputs of similar age from Frontiers in Physiology
#244
of 359 outputs
Altmetric has tracked 23,007,887 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,760 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,178 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 359 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.