Thiago M. Fidale, Hanna K. M. Antunes, Luciano Alex dos Santos, Fernanda Rodrigues de Souza, Simone R. Deconte, Francyelle Borges Rosa de Moura, Matheus M. Mantovani, Poliana Rodrigues Alves Duarte, Leonardo Roever, Elmiro S. Resende
Abstract
Cardiotoxicity is one of the most significant adverse effects of the oncologic treatment with doxorubicin, which is responsible for a substantial morbid and mortality. The occurrence of heart failure with ventricular dysfunction may lead to severe cardiomyopathy and ultimately to death. Studies have focused on the effects of leucine supplementation as a strategy to minimize or revert the clinical condition of induced proteolysis by several clinical onsets. However, the impact of leucine supplementation in heart failure induced by doxorubicin is unknown. Therefore, the objective of this work is to evaluate the effects of leucine supplementation on the cardiotoxicity in the heart of rats treated with doxorubicin. Rats treated with a 7.5 mg/kg cumulative dose of doxorubicin for 14 days presented a dilatation of the left ventricle (LV), and a reduction of the ejection fraction (FE). The 5% supplementation of leucine in the rats' food prevented the malfunctioning of the LV when administered with doxorubicin. Some alterations in the extracellular matrix remodeling were confirmed by the increase of collagen fibers in the doxorubicin group, which did not increase when the treatment was associated with leucine supplementation. Leucine attenuates heart failure in this experimental model with doxorubicin. Such protection is followed by the maintenance of interstitial collagen fibers.
Pharmacology, Toxicology and Pharmaceutical Science
2
10%
Agricultural and Biological Sciences
2
10%
Biochemistry, Genetics and Molecular Biology
1
5%
Sports and Recreations
1
5%
Other
1
5%
Unknown
8
38%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2018.
All research outputs
#20,459,801
of 23,016,919 outputs
Outputs from Frontiers in Physiology
#9,481
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Outputs of similar age
#378,724
of 441,888 outputs
Outputs of similar age from Frontiers in Physiology
#208
of 299 outputs
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