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Mendeley readers
Attention Score in Context
| Title |
Zinc-α2-Glycoprotein Is Associated with Obesity in Chinese People and HFD-Induced Obese Mice
|
|---|---|
| Published in |
Frontiers in Physiology, February 2018
|
| DOI | 10.3389/fphys.2018.00062 |
| Pubmed ID | |
| Authors |
Meijuan Liu, Huijuan Zhu, Yufei Dai, Hui Pan, Naishi Li, Linjie Wang, Hongbo Yang, Kemin Yan, Fengying Gong |
| Abstract |
Zinc-α2-glycoprotein (ZAG) plays an important role in the regulation of body weight, body fat, and glucose metabolism. In this study, we first measured ZAG levels in serum andZAGmRNA levels in subcutaneous white adipose tissue (sWAT) among overweight/obese patients and lean control subjects. Second, we investigated the effects of ZAG administration on the body weight, body fat and glucose metabolism of high-fat diet (HFD)-induced obese ICR mice and the possible mechanisms involved. The results showed that serum ZAG and mRNA levels in sWAT were significantly decreased in overweight/obese patients and that both showed a negative association with body mass index (BMI) and body weight after adjustment for age and sex. Further partial correlation analysis found thatZAGmRNA expression was positively related with several WAT browning-related genes, including uncoupling protein 1 (UCP1) (r= 0.67) and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1a) (r= 0.60), in the sWAT of all subjects. Additionally, intraperitoneal injection of a ZAG expression plasmid (5 μg/injection, four times a week) in HFD-induced obese mice for 8 weeks demonstrated that ZAG overexpression significantly decreased body weight and WAT mass, and greatly increased the glucose tolerance of obese mice, as shown by the intraperitoneal glucose tolerance test (IPGTT) and intraperitoneal insulin tolerance test (IPITT). The staining of UCP1-positive adipocytes was significantly stronger in the sWAT of ZAG-treated obese mice than in that of obese control mice. The mRNA and protein levels of PGC1α in sWAT were significantly increased to 2.2- and 5.3-fold, respectively, compared with HFD obese mice, and there was a strong positive correlation between the expression levels ofZagandPgc1α in mouse sWAT (r= 0.74). A similar phenomenon was also observed in visceral white adipose tissue (vWAT): the mRNA and protein levels of PGC1α were increased to 1.9- and 3.6-fold, respectively, when obese mice were treated with ZAG. In conclusion, ZAG levels in both sWAT and serum are inversely related with BMI and body weight in Chinese subjects. The action of ZAG on body weight, fat mass and glucose metabolism may be realized through activating PGC1α expression in sWAT and vWAT, then promoting WAT browning in obese mice. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 13% |
| Student > Master | 5 | 13% |
| Student > Ph. D. Student | 5 | 13% |
| Unspecified | 2 | 5% |
| Student > Doctoral Student | 2 | 5% |
| Other | 5 | 13% |
| Unknown | 14 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 21% |
| Medicine and Dentistry | 3 | 8% |
| Unspecified | 2 | 5% |
| Chemistry | 2 | 5% |
| Agricultural and Biological Sciences | 2 | 5% |
| Other | 4 | 11% |
| Unknown | 17 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2018.
All research outputs
#20,462,806
of 23,020,670 outputs
Outputs from Frontiers in Physiology
#9,487
of 13,773 outputs
Outputs of similar age
#375,887
of 437,841 outputs
Outputs of similar age from Frontiers in Physiology
#217
of 302 outputs
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So far Altmetric has tracked 13,773 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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