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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Skeletal Muscle Pyruvate Dehydrogenase Phosphorylation and Lactate Accumulation During Sprint Exercise in Normoxia and Severe Acute Hypoxia: Effects of Antioxidants
|
|---|---|
| Published in |
Frontiers in Physiology, March 2018
|
| DOI | 10.3389/fphys.2018.00188 |
| Pubmed ID | |
| Authors |
David Morales-Alamo, Borja Guerra, Alfredo Santana, Marcos Martin-Rincon, Miriam Gelabert-Rebato, Cecilia Dorado, José A. L. Calbet |
| Abstract |
Compared to normoxia, during sprint exercise in severe acute hypoxia the glycolytic rate is increased leading to greater lactate accumulation, acidification, and oxidative stress. To determine the role played by pyruvate dehydrogenase (PDH) activation and reactive nitrogen and oxygen species (RNOS) in muscle lactate accumulation, nine volunteers performed a single 30-s sprint (Wingate test) on four occasions: two after the ingestion of placebo and another two following the intake of antioxidants, while breathing either hypoxic gas (PIO2= 75 mmHg) or room air (PIO2= 143 mmHg).Vastus lateralismuscle biopsies were obtained before, immediately after, 30 and 120 min post-sprint. Antioxidants reduced the glycolytic rate without altering performance or VO2. Immediately after the sprints, Ser293- and Ser300-PDH-E1α phosphorylations were reduced to similar levels in all conditions (~66 and 91%, respectively). However, 30 min into recovery Ser293-PDH-E1α phosphorylation reached pre-exercise values while Ser300-PDH-E1α was still reduced by 44%. Thirty minutes after the sprint Ser293-PDH-E1α phosphorylation was greater with antioxidants, resulting in 74% higher muscle lactate concentration. Changes in Ser293and Ser300-PDH-E1α phosphorylation from pre to immediately after the sprints were linearly related after placebo (r= 0.74,P< 0.001;n= 18), but not after antioxidants ingestion (r= 0.35,P= 0.15). In summary, lactate accumulation during sprint exercise in severe acute hypoxia is not caused by a reduced activation of the PDH. The ingestion of antioxidants is associated with increased PDH re-phosphorylation and slower elimination of muscle lactate during the recovery period. Ser293re-phosphorylates at a faster rate than Ser300-PDH-E1α during the recovery period, suggesting slightly different regulatory mechanisms. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 7 | 23% |
| United Kingdom | 3 | 10% |
| Greece | 3 | 10% |
| Chile | 2 | 7% |
| Australia | 2 | 7% |
| Switzerland | 2 | 7% |
| Slovenia | 1 | 3% |
| Canada | 1 | 3% |
| Mexico | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 5 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 18 | 60% |
| Members of the public | 12 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 19% |
| Student > Ph. D. Student | 7 | 13% |
| Lecturer | 4 | 7% |
| Student > Bachelor | 4 | 7% |
| Other | 4 | 7% |
| Other | 9 | 17% |
| Unknown | 16 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 10 | 19% |
| Biochemistry, Genetics and Molecular Biology | 7 | 13% |
| Medicine and Dentistry | 5 | 9% |
| Nursing and Health Professions | 4 | 7% |
| Agricultural and Biological Sciences | 4 | 7% |
| Other | 7 | 13% |
| Unknown | 17 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2021.
All research outputs
#2,154,642
of 24,717,692 outputs
Outputs from Frontiers in Physiology
#1,185
of 15,186 outputs
Outputs of similar age
#45,792
of 337,181 outputs
Outputs of similar age from Frontiers in Physiology
#45
of 415 outputs
Altmetric has tracked 24,717,692 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,186 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,181 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 415 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.