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Beneficial Effects of Elderly Tailored Mediterranean Diet on the Proteasomal Proteolysis

Overview of attention for article published in Frontiers in Physiology, May 2018
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Title
Beneficial Effects of Elderly Tailored Mediterranean Diet on the Proteasomal Proteolysis
Published in
Frontiers in Physiology, May 2018
DOI 10.3389/fphys.2018.00457
Pubmed ID
Authors

Sophia Athanasopoulou, Niki Chondrogianni, Aurelia Santoro, Konstantina Asimaki, Vasiliki Delitsikou, Konstantinos Voutetakis, Cristina Fabbri, Barbara Pietruszka, Joanna Kaluza, Claudio Franceschi, Efstathios S. Gonos

Abstract

Aging is a multifactorial process characterized by the accumulation of proteins undergoing oxidative modifications, either due to enhanced levels of oxidative stress or due to their decreased clearance; both facts are related to the establishment of chronic inflammatory processes. These processes are directly associated with functional and structural modifications of a key cellular component, namely the proteasome. In this study, levels of oxidized proteins, along with proteasome and immunoproteasome composition and activity on a selected group of 120 elderly volunteers were analyzed before and after the administration of a specific dietary protocol, based on an elderly tailored Mediterranean diet (the "NU-AGE diet"). A significant negative correlation between levels of oxidized/carbonylated proteins and proteasome function was confirmed, both before and after intervention. Furthermore, it was demonstrated that subgroups of non-frail subjects and women receive a greater benefit after the intervention, concerning specifically the proteasome content and activity. These data highlight the putative beneficial effects of Mediterranean diet on the major cellular proteolytic mechanism, the proteasome, in elderly people.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 16%
Student > Ph. D. Student 4 13%
Other 3 9%
Researcher 3 9%
Student > Doctoral Student 2 6%
Other 7 22%
Unknown 8 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 22%
Biochemistry, Genetics and Molecular Biology 4 13%
Nursing and Health Professions 4 13%
Immunology and Microbiology 3 9%
Medicine and Dentistry 2 6%
Other 2 6%
Unknown 10 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2022.
All research outputs
#18,583,054
of 23,016,919 outputs
Outputs from Frontiers in Physiology
#8,226
of 13,772 outputs
Outputs of similar age
#252,864
of 326,091 outputs
Outputs of similar age from Frontiers in Physiology
#304
of 489 outputs
Altmetric has tracked 23,016,919 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,772 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,091 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 489 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.