Title |
The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer
|
---|---|
Published in |
Frontiers in Physiology, May 2018
|
DOI | 10.3389/fphys.2018.00557 |
Pubmed ID | |
Authors |
Marta B. Wysocka, Katarzyna Pietraszek-Gremplewicz, Dorota Nowak |
Abstract |
Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by adipose tissue. Extensive tissue distribution of apelin and its receptor suggests, that it could be involved in many physiological processes including regulation of blood pressure, body fluid homeostasis, endocrine stress response, cardiac contractility, angiogenesis, and energy metabolism. Additionally, this peptide participates in pathological processes, such as heart failure, obesity, diabetes, and cancer. In this article, we review current knowledge about the role of apelin in organ and tissue pathologies. We also summarize the mechanisms by which apelin and its receptor mediate the regulation of physiological and pathological processes. Moreover, we put forward an indication of apelin as a biomarker predicting cardiac diseases and various types of cancer. A better understanding of the function of apelin and its receptor in pathologies might lead to the development of new medical compounds. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 168 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 23 | 14% |
Researcher | 20 | 12% |
Student > Master | 19 | 11% |
Student > Bachelor | 17 | 10% |
Other | 7 | 4% |
Other | 18 | 11% |
Unknown | 64 | 38% |
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Medicine and Dentistry | 20 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 5% |
Agricultural and Biological Sciences | 7 | 4% |
Neuroscience | 6 | 4% |
Other | 20 | 12% |
Unknown | 71 | 42% |