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Age-Related Changes in Human Schlemm’s Canal: An in Vivo Optical Coherence Tomography-Based Study

Overview of attention for article published in Frontiers in Physiology, June 2018
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Title
Age-Related Changes in Human Schlemm’s Canal: An in Vivo Optical Coherence Tomography-Based Study
Published in
Frontiers in Physiology, June 2018
DOI 10.3389/fphys.2018.00630
Pubmed ID
Authors

Yujin Zhao, Junyi Chen, Xiaobo Yu, Jianjiang Xu, Xinghuai Sun, Jiaxu Hong

Abstract

Purpose: To investigate age-related changes in human Schlemm's canal (SC) using spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 125 normal eyes were imaged using SD-OCT nasally and temporally. The age-related variations of SC sagittal diameter and cross-sectional area (CSA) from four age groups [A (16-20 years), B (21-40 years), C (41-60 years), and D (61-80 years)] were analyzed with Spearman correlation. Results: The positive detection rates of SC showed a significantly downward trend with age. The mean CSA was 13,296 ± 1,897 μm2 nasally and 14,552 ± 2,589 μm2 temporally. The mean CSA was significantly larger in the temporal than in the nasal region (P < 0.05). Nasal CSA values varied among the four age groups (P = 0.004). Conclusion: Our study found for the first time that SC in vivo exhibits a morphological variant with age in healthy humans. Clinicians may need to consider this phenomenon when performing examinations targeting SC for glaucoma patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 4 24%
Other 2 12%
Professor 1 6%
Student > Master 1 6%
Researcher 1 6%
Other 1 6%
Unknown 7 41%
Readers by discipline Count As %
Medicine and Dentistry 5 29%
Computer Science 2 12%
Engineering 1 6%
Unknown 9 53%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2018.
All research outputs
#20,525,274
of 23,094,276 outputs
Outputs from Frontiers in Physiology
#9,525
of 13,842 outputs
Outputs of similar age
#289,341
of 329,791 outputs
Outputs of similar age from Frontiers in Physiology
#387
of 497 outputs
Altmetric has tracked 23,094,276 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,842 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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