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Conjugating Existing Clinical Drugs With Gold Nanoparticles for Better Treatment of Heart Diseases

Overview of attention for article published in Frontiers in Physiology, May 2018
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Title
Conjugating Existing Clinical Drugs With Gold Nanoparticles for Better Treatment of Heart Diseases
Published in
Frontiers in Physiology, May 2018
DOI 10.3389/fphys.2018.00642
Pubmed ID
Authors

Jingwen Zhang, Aiqun Ma, Lijun Shang

Abstract

Developing new methods to treat heart diseases is always a focus for basic research and clinical applications. Existing drugs have strong side-effects and also require lifetime administration for patients. Recent attempts of using nanoparticles (NPs) in treating atherosclerosis in animals and some heart diseases such as heart failure and endocarditis have provided hopes for better drug delivery and reducing of drug side-effects. In this mini-review, we summarize the present applications of using gold nanoparticles (GNPs) as a new drug delivery system in diseased hearts and of the assessment of toxicity in using GNPs. We suggest that conjugating existing clinical drugs with GNPs is a favorable choice to provide "new and double-enhanced" potentiality to those existing drugs in treating heart diseases. Other applications of using NPs in the treatment of heart diseases including using drugs in nano-form and coating drugs with a surface of relevant NP are also discussed.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 15%
Student > Postgraduate 4 10%
Student > Master 4 10%
Student > Ph. D. Student 4 10%
Student > Doctoral Student 2 5%
Other 6 15%
Unknown 13 33%
Readers by discipline Count As %
Medicine and Dentistry 6 15%
Biochemistry, Genetics and Molecular Biology 6 15%
Materials Science 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Engineering 2 5%
Other 6 15%
Unknown 14 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2018.
All research outputs
#20,523,725
of 23,092,602 outputs
Outputs from Frontiers in Physiology
#9,523
of 13,838 outputs
Outputs of similar age
#290,615
of 331,258 outputs
Outputs of similar age from Frontiers in Physiology
#380
of 488 outputs
Altmetric has tracked 23,092,602 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,838 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,258 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 488 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.