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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Muscle Atrophy Due to Nerve Damage Is Accompanied by Elevated Myofibrillar Protein Synthesis Rates
|
|---|---|
| Published in |
Frontiers in Physiology, August 2018
|
| DOI | 10.3389/fphys.2018.01220 |
| Pubmed ID | |
| Authors |
Henning T. Langer, Joan M. G. Senden, Annemie P. Gijsen, Stefan Kempa, Luc J. C. van Loon, Simone Spuler |
| Abstract |
Muscle loss is a severe complication of many medical conditions such as cancer, cardiac failure, muscular dystrophies, and nerve damage. The contribution of myofibrillar protein synthesis (MPS) to the loss of muscle mass after nerve damage is not clear. Using deuterium oxide (D2O) labeling, we demonstrate that MPS is significantly increased in rat m.tibialis anterior (TA) compared to control (3.23 ± 0.72 [damaged] to 2.09 ± 0.26%∗day-1 [control]) after 4 weeks of nerve constriction injury. This is the case despite substantial loss of mass of the TA (350 ± 96 mg [damaged] to 946 ± 361 mg [control]). We also show that expression of regulatory proteins involved with MPS (p70s6k1: 2.4 ± 0.3 AU [damaged] to 1.8 ± 0.2 AU [control]) and muscle protein breakdown (MPB) (MAFbx: 5.3 ± 1.2 AU [damaged] to 1.4 ± 0.4 AU [control]) are increased in nerve damaged muscle. Furthermore, the expression of p70s6k1 correlates with MPS rates (r2 = 0.57). In conclusion, this study shows that severe muscle wasting following nerve damage is accompanied by increased as opposed to decreased MPS. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 17% |
| United Kingdom | 4 | 13% |
| Japan | 2 | 7% |
| Greece | 2 | 7% |
| Italy | 1 | 3% |
| India | 1 | 3% |
| Spain | 1 | 3% |
| Switzerland | 1 | 3% |
| Canada | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 11 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 57% |
| Scientists | 12 | 40% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 70 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 17% |
| Student > Bachelor | 9 | 13% |
| Student > Master | 9 | 13% |
| Researcher | 7 | 10% |
| Other | 4 | 6% |
| Other | 9 | 13% |
| Unknown | 20 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 23% |
| Medicine and Dentistry | 8 | 11% |
| Nursing and Health Professions | 6 | 9% |
| Agricultural and Biological Sciences | 6 | 9% |
| Engineering | 4 | 6% |
| Other | 10 | 14% |
| Unknown | 20 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2020.
All research outputs
#1,967,029
of 23,342,092 outputs
Outputs from Frontiers in Physiology
#1,081
of 14,074 outputs
Outputs of similar age
#42,689
of 335,900 outputs
Outputs of similar age from Frontiers in Physiology
#53
of 473 outputs
Altmetric has tracked 23,342,092 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,074 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,900 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 473 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.