Title |
Plant Lessons: Exploring ABCB Functionality Through Structural Modeling
|
---|---|
Published in |
Frontiers in Plant Science, January 2012
|
DOI | 10.3389/fpls.2011.00108 |
Pubmed ID | |
Authors |
Aurélien Bailly, Haibing Yang, Enrico Martinoia, Markus Geisler, Angus S. Murphy |
Abstract |
In contrast to mammalian ABCB1 proteins, narrow substrate specificity has been extensively documented for plant orthologs shown to catalyze the transport of the plant hormone, auxin. Using the crystal structures of the multidrug exporters Sav1866 and MmABCB1 as templates, we have developed structural models of plant ABCB proteins with a common architecture. Comparisons of these structures identified kingdom-specific candidate substrate-binding regions within the translocation chamber formed by the transmembrane domains of ABCBs from the model plant Arabidopsis. These results suggest an early evolutionary divergence of plant and mammalian ABCBs. Validation of these models becomes a priority for efforts to elucidate ABCB function and manipulate this class of transporters to enhance plant productivity and quality. |
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Country | Count | As % |
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Unknown | 1 | 100% |
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Mendeley readers
Geographical breakdown
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United Kingdom | 1 | 2% |
Mexico | 1 | 2% |
United States | 1 | 2% |
Belgium | 1 | 2% |
Unknown | 46 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 28% |
Student > Ph. D. Student | 11 | 22% |
Student > Doctoral Student | 6 | 12% |
Student > Master | 5 | 10% |
Professor | 3 | 6% |
Other | 7 | 14% |
Unknown | 4 | 8% |
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Unknown | 6 | 12% |