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Endoplasmic reticulum-mediated protein quality control in Arabidopsis

Overview of attention for article published in Frontiers in Plant Science, April 2014
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Title
Endoplasmic reticulum-mediated protein quality control in Arabidopsis
Published in
Frontiers in Plant Science, April 2014
DOI 10.3389/fpls.2014.00162
Pubmed ID
Authors

Yidan Liu, Jianming Li

Abstract

A correct three-dimensional structure is crucial for the physiological functions of a protein, yet the folding of proteins to acquire native conformation is a fundamentally error-prone process. Eukaryotic organisms have evolved a highly conserved endoplasmic reticulum-mediated protein quality control (ERQC) mechanism to monitor folding processes of secretory and membrane proteins, allowing export of only correctly folded proteins to their physiological destinations, retaining incompletely/mis-folded ones in the ER for additional folding attempts, marking and removing terminally misfolded ones via a unique multiple-step degradation process known as ER-associated degradation (ERAD). Most of our current knowledge on ERQC and ERAD came from genetic and biochemical investigations in yeast and mammalian cells. Recent studies in the reference plant Arabidopsis thaliana uncovered homologous components and similar mechanisms in plants for monitoring protein folding and for retaining, repairing, and removing misfolded proteins. These studies also revealed critical roles of the plant ERQC/ERAD systems in regulating important biochemical/physiological processes, such as abiotic stress tolerance and plant defense. In this review, we discuss our current understanding about the molecular components and biochemical mechanisms of the plant ERQC/ERAD system in comparison to yeast and mammalian systems.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 124 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 34 27%
Student > Bachelor 18 15%
Student > Master 17 14%
Researcher 12 10%
Student > Doctoral Student 4 3%
Other 14 11%
Unknown 25 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 57 46%
Biochemistry, Genetics and Molecular Biology 33 27%
Unspecified 1 <1%
Computer Science 1 <1%
Immunology and Microbiology 1 <1%
Other 4 3%
Unknown 27 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2014.
All research outputs
#20,228,822
of 22,754,104 outputs
Outputs from Frontiers in Plant Science
#15,956
of 20,059 outputs
Outputs of similar age
#193,159
of 227,058 outputs
Outputs of similar age from Frontiers in Plant Science
#84
of 153 outputs
Altmetric has tracked 22,754,104 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 20,059 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 153 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.