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Plant Metabolic Engineering Strategies for the Production of Pharmaceutical Terpenoids

Overview of attention for article published in Frontiers in Plant Science, November 2016
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Title
Plant Metabolic Engineering Strategies for the Production of Pharmaceutical Terpenoids
Published in
Frontiers in Plant Science, November 2016
DOI 10.3389/fpls.2016.01647
Pubmed ID
Authors

Xu Lu, Kexuan Tang, Ping Li

Abstract

Pharmaceutical terpenoids belong to the most diverse class of natural products. They have significant curative effects on a variety of diseases, such as cancer, cardiovascular diseases, malaria and Alzheimer's disease. Nowadays, elicitors, including biotic and abiotic elicitors, are often used to activate the pathway of secondary metabolism and enhance the production of target terpenoids. Based on Agrobacterium-mediated genetic transformation, several plant metabolic engineering strategies hold great promise to regulate the biosynthesis of pharmaceutical terpenoids. Overexpressing terpenoids biosynthesis pathway genes in homologous and ectopic plants is an effective strategy to enhance the yield of pharmaceutical terpenoids. Another strategy is to suppress the expression of competitive metabolic pathways. In addition, global regulation which includes regulating the relative transcription factors, endogenous phytohormones and primary metabolism could also markedly increase their yield. All these strategies offer great opportunities to enhance the supply of scarce terpenoids drugs, reduce the price of expensive drugs and improve people's standards of living.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 204 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
Unknown 203 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 17%
Researcher 27 13%
Student > Master 24 12%
Student > Bachelor 19 9%
Student > Doctoral Student 13 6%
Other 26 13%
Unknown 60 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 59 29%
Biochemistry, Genetics and Molecular Biology 48 24%
Chemistry 7 3%
Environmental Science 5 2%
Medicine and Dentistry 5 2%
Other 11 5%
Unknown 69 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2017.
All research outputs
#15,437,553
of 22,947,506 outputs
Outputs from Frontiers in Plant Science
#10,945
of 20,366 outputs
Outputs of similar age
#197,652
of 313,259 outputs
Outputs of similar age from Frontiers in Plant Science
#209
of 440 outputs
Altmetric has tracked 22,947,506 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 20,366 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,259 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 440 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.