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Lead Phytochemicals for Anticancer Drug Development

Overview of attention for article published in Frontiers in Plant Science, November 2016
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Title
Lead Phytochemicals for Anticancer Drug Development
Published in
Frontiers in Plant Science, November 2016
DOI 10.3389/fpls.2016.01667
Pubmed ID
Authors

Sukhdev Singh, Bhupender Sharma, Shamsher S. Kanwar, Ashok Kumar

Abstract

Cancer is a serious concern at present. A large number of patients die each year due to cancer illnesses in spite of several interventions available. Development of an effective and side effects lacking anticancer therapy is the trending research direction in healthcare pharmacy. Chemical entities present in plants proved to be very potential in this regard. Bioactive phytochemicals are preferential as they pretend differentially on cancer cells only, without altering normal cells. Carcinogenesis is a complex process and includes multiple signaling events. Phytochemicals are pleiotropic in their function and target these events in multiple manners; hence they are most suitable candidate for anticancer drug development. Efforts are in progress to develop lead candidates from phytochemicals those can block or retard the growth of cancer without any side effect. Several phytochemicals manifest anticancer function in vitro and in vivo. This article deals with these lead phytomolecules with their action mechanisms on nuclear and cellular factors involved in carcinogenesis. Additionally, druggability parameters and clinical development of anticancer phytomolecules have also been discussed.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 583 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Croatia 2 <1%
India 1 <1%
Unknown 580 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 89 15%
Student > Ph. D. Student 75 13%
Student > Master 68 12%
Researcher 44 8%
Student > Postgraduate 19 3%
Other 68 12%
Unknown 220 38%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 108 19%
Pharmacology, Toxicology and Pharmaceutical Science 57 10%
Agricultural and Biological Sciences 51 9%
Chemistry 39 7%
Medicine and Dentistry 18 3%
Other 60 10%
Unknown 250 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2016.
All research outputs
#20,355,479
of 22,903,988 outputs
Outputs from Frontiers in Plant Science
#16,218
of 20,327 outputs
Outputs of similar age
#270,520
of 312,900 outputs
Outputs of similar age from Frontiers in Plant Science
#317
of 440 outputs
Altmetric has tracked 22,903,988 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 20,327 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,900 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 440 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.