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Mendeley readers
Attention Score in Context
| Title |
The Binding Mechanism Between Inositol Phosphate (InsP) and the Jasmonate Receptor Complex: A Computational Study
|
|---|---|
| Published in |
Frontiers in Plant Science, July 2018
|
| DOI | 10.3389/fpls.2018.00963 |
| Pubmed ID | |
| Authors |
Mengqi Cui, Juan Du, XiaoJun Yao |
| Abstract |
Jasmonates are critical plant hormones, mediating stress response in plants and regulating plant growth and development. The jasmonate receptor is a multi-component complex, composed of Arabidopsis SKP-LIKE PROTEIN1 (ASK1), CORONATINE INSENSITIVE 1 (COI1), inositol phosphate (InsP), and jasmonate ZIM-domain protein (JAZ). COI1 acts as multi-component signaling hub that binds with each component. InsP is suggested to play important roles in the hormone perception. How InsP binds with COI1 and the structural changes in COI1 upon binding with InsP, JA-Ile, and JAZ are not well understood. In this study, we integrated multiple computational methods, such as molecular docking, molecular dynamics simulations, residue interaction network analysis and binding free energy calculation, to explore the effect of InsP on the dynamic behavior of COI1 and the recognition mechanism of each component of the jasmonate receptor complex. We found that upon binding with InsP, JA-Ile, and JAZ1, the structure of COI1 becomes more compact. The binding of InsP with COI1 stabilizes the conformation of COI1 and promotes the binding between JA-Ile or JAZ1 and COI1. Analysis of the network parameters led to the identification of some hub nodes in this network, including Met88, His118, Arg120, Arg121, Arg346, Tyr382, Arg409, Trp467, and Lys492. The structural and dynamic details will be helpful for understanding the recognition mechanism of each component and the discovery and design of novel jasmonate signaling pathway modulators. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 19% |
| Researcher | 2 | 13% |
| Unspecified | 1 | 6% |
| Student > Bachelor | 1 | 6% |
| Student > Doctoral Student | 1 | 6% |
| Other | 2 | 13% |
| Unknown | 6 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 25% |
| Chemistry | 2 | 13% |
| Biochemistry, Genetics and Molecular Biology | 2 | 13% |
| Unspecified | 1 | 6% |
| Physics and Astronomy | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 5 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2018.
All research outputs
#20,529,173
of 23,098,660 outputs
Outputs from Frontiers in Plant Science
#16,586
of 20,719 outputs
Outputs of similar age
#287,709
of 329,174 outputs
Outputs of similar age from Frontiers in Plant Science
#424
of 482 outputs
Altmetric has tracked 23,098,660 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 20,719 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 482 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.