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Neural correlates of saccadic inhibition in healthy elderly and patients with amnestic mild cognitive impairment

Overview of attention for article published in Frontiers in Psychology, January 2013
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Title
Neural correlates of saccadic inhibition in healthy elderly and patients with amnestic mild cognitive impairment
Published in
Frontiers in Psychology, January 2013
DOI 10.3389/fpsyg.2013.00467
Pubmed ID
Authors

K. K. Alichniewicz, F. Brunner, H. H. Klünemann, M. W. Greenlee

Abstract

Performance on tasks that require saccadic inhibition declines with age and altered inhibitory functioning has also been reported in patients with Alzheimer's disease. Although mild cognitive impairment (MCI) is assumed to be a high-risk factor for conversion to AD, little is known about changes in saccadic inhibition and its neural correlates in this condition. Our study determined whether the neural activation associated with saccadic inhibition is altered in persons with amnestic mild cognitive impairment (aMCI). Functional magnetic resonance imaging (fMRI) revealed decreased activation in parietal lobe in healthy elderly persons compared to young persons and decreased activation in frontal eye fields in aMCI patients compared to healthy elderly persons during the execution of anti-saccades. These results illustrate that the decline in inhibitory functions is associated with impaired frontal activation in aMCI. This alteration in function might reflect early manifestations of AD and provide new insights in the neural activation changes that occur in pathological ageing.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Poland 1 1%
Germany 1 1%
Unknown 89 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 21%
Researcher 17 19%
Professor 7 8%
Student > Bachelor 6 7%
Student > Doctoral Student 6 7%
Other 12 13%
Unknown 24 26%
Readers by discipline Count As %
Psychology 31 34%
Neuroscience 16 18%
Medicine and Dentistry 7 8%
Linguistics 3 3%
Engineering 3 3%
Other 4 4%
Unknown 27 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2013.
All research outputs
#20,196,270
of 22,714,025 outputs
Outputs from Frontiers in Psychology
#23,854
of 29,507 outputs
Outputs of similar age
#248,772
of 280,752 outputs
Outputs of similar age from Frontiers in Psychology
#851
of 969 outputs
Altmetric has tracked 22,714,025 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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