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The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects

Overview of attention for article published in Frontiers in Psychology, October 2019
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Title
The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects
Published in
Frontiers in Psychology, October 2019
DOI 10.3389/fpsyg.2019.02218
Pubmed ID
Authors

Dan Wang, Tingting Guo, Qi Guo, Shun Zhang, Jinghuan Zhang, Jing Luo, GeseDNA Research Team, Leilei Zhang, Qian Sun, Zenan Dou, Yanmeng Zou, Shan Guan, Hoyin Lo, Lingzhi Song

Abstract

Although previous evidence has suggested that there is a genetic link between schizophrenia and creativity, the specific genetic variants that underlie the link are still largely unknown. To further explore the potential genetic link between schizophrenia and creativity, in a sample of 580 healthy Han Chinese subjects, this study aimed to (1) validate the role of Neuregulin 1 (NRG1) rs6994992 (one schizophrenia risk variant that has been previously linked to creativity in the European population) in the relationship between schizophrenia and creativity and (2) explore the associations between 10 other schizophrenia risk variants and creativity. For NRG1 rs6994992, the result validated its association with creativity measures. However, since NRG1 rs6994992 is not a schizophrenia risk variant in the Han Chinese population, the validated association suggested that ethnic difference may exist in the relationship between NRG1 rs6994992, schizophrenia and creativity. For other schizophrenia risk variants, the result only demonstrated a nominal association between ZNF536 rs2053079 and creativity measures which would not survive correction for multiple testing. No association between polygenic risk score for these 10 schizophrenia risk variants and creativity measures was observed. In conclusion, this study provides limited evidence for the associations between these schizophrenia risk variants and creativity in healthy Han Chinese subjects. Future studies are warranted to better understand the potential genetic link between schizophrenia and creativity.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 11%
Student > Master 3 11%
Other 2 7%
Student > Bachelor 2 7%
Lecturer 2 7%
Other 4 14%
Unknown 12 43%
Readers by discipline Count As %
Psychology 5 18%
Biochemistry, Genetics and Molecular Biology 2 7%
Unspecified 1 4%
Nursing and Health Professions 1 4%
Immunology and Microbiology 1 4%
Other 5 18%
Unknown 13 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2019.
All research outputs
#14,175,881
of 23,170,347 outputs
Outputs from Frontiers in Psychology
#14,441
of 30,680 outputs
Outputs of similar age
#185,739
of 349,851 outputs
Outputs of similar age from Frontiers in Psychology
#360
of 628 outputs
Altmetric has tracked 23,170,347 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 30,680 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 349,851 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 628 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.