Title |
Molecular Neurobiology of Depression: PET Findings on the Elusive Correlation with Symptom Severity
|
---|---|
Published in |
Frontiers in Psychiatry, January 2013
|
DOI | 10.3389/fpsyt.2013.00008 |
Pubmed ID | |
Authors |
Donald F. Smith, Steen Jakobsen |
Abstract |
Molecular mechanisms in the brain are assumed to cause the symptoms and severity of neuropsychiatric disorders. This review concerns the elusive nature of relationships between the severity of depressive disorders and neuromolecular processes studied by positron emission tomography (PET). Recent PET studies of human depression have focused on serotonergic, dopaminergic, muscarinic, nicotinic, and GABAergic receptors, as well as central processes dependent on monoamine oxidase, phosphodiesterase type 4, amyloid plaques, neurofibrillar tangles, and P-glycoprotein. We find that reliable causal links between neuromolecular mechanisms and relief from depressive disorders have yet to be convincingly demonstrated. This situation may contribute to the currently limited use of PET for exploring the neuropathways that are currently viewed as being responsible for beneficial effects of antidepressant treatment regimes. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Russia | 1 | 17% |
Finland | 1 | 17% |
Switzerland | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Malaysia | 1 | 1% |
United States | 1 | 1% |
Canada | 1 | 1% |
Unknown | 68 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 14 | 20% |
Student > Ph. D. Student | 10 | 14% |
Student > Master | 9 | 13% |
Researcher | 7 | 10% |
Student > Doctoral Student | 6 | 8% |
Other | 12 | 17% |
Unknown | 13 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 15% |
Neuroscience | 11 | 15% |
Psychology | 10 | 14% |
Agricultural and Biological Sciences | 10 | 14% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Other | 7 | 10% |
Unknown | 19 | 27% |